Let's talk about portability. As we all know, there are some differences between operating systems. Most operating systems follow the POSIX standard, but there are always some platform specific differences-- a missing header file here, a nonstandard libc function there, and so forth.
Build systems can't just wave a magic wand and make these differences disappear. The programmer is still responsible for implementing workarounds for things that are missing, and being aware of specific limitations that a given operating system may have. For example, older versions of Linux using the ext3 filesystem could only have 16,384 subdirectories in a directory. There is nothing that the build system can do to insulate programmers from this reality.
So, in a very real sense, build systems can only make portability worse, but never better. How can a build system make portability worse?
autotools does all three of these things. You end up writing snippets of shell scripts in configure.ac, Makefile.am, and other files. These scripts may work fine on your own platform when using your version of Bash, but they tend to fail on other platforms.