0. DOCID:3676 SCORE: 0.0101116612580901
DOCNO: 189898
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radiotherapy
QUALIFIER: radiotherapy
AUTHOR: C A Perez CA
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Radiation therapy in the management of carcinoma of the lung.
PUBDATE: 19770201
Carcinoma of the lung is the most common cancer in men in the United States and a major cause of death. This is due to the inadequate techniques for screening of high-risk patients and for detection of the tumor in early stages, before distant dissemination occurs. Although some progress has been made in the past, particularly in improving the knowledge of natural history and pathological characteristics of the disease, and there are better indications for surgical treatment and irradiation and the effective use of cytotoxic agents in selected groups of patients, particularly those with small cell undifferentiated carcinoma, the mortality rate is still very high. A great deal of investigation remains to be done in carcinoma of the lung concerning the basic cell kinetics of the tumor and the optimal conditions for the use of surgery, irradiation, chemotherapy or combinations of these agents in the treatment of these patients before survival rates can be substantially improved. Since the most important factor in patient mortality is distant tumor dissemination, it must be stressed that parameters other than survival should be used to evaluate the effectiveness of irradiation, surgery or combinations in the control of local and regional bronchogenic carcinoma. These efforts should be intensified through properly designed clinical trials.

1. DOCID:3156 SCORE: 0.0067288469725616
DOCNO: 974001
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: urine
QUALIFIER: urine
QUALIFIER: urine
AUTHOR: F Gielen F
AUTHOR: J Dequeker J
AUTHOR: A Drochmans A
AUTHOR: J Wildiers J
AUTHOR: M Merlevede M
PUBTYPE: Journal Article
JOURNALTITLE: British journal of cancer.
COUNTRY: ENGLAND
TITLE: Relevance of hydroxyproline excretion to bone metastasis in breast cancer.
PUBDATE: 19760901
In 181 consecutive patients with breast cancer, urinary hydroxyproline excretion has been critically evaluated in conjunction with clinical, biochemical, radiological and scintigraphic parameters. The urinary hydroxyproline/creatinine ratio is a sensitive index of the presence of bone metastases. Urinary hydroxyproline excretion is a reliable method of selecting those patients whose elevated serum alkaline phosphatase is secondary to bone disease rather than liver idsease. The estimation of hydroxyproline excretion furthermore gives information on the activity of bone metastasis, and its response to treatment, which cannot be given by radiological or scintigraphic methods. It is doubtful whether urinary hydroxyproline estimation will help to detect bone metastases before they are apparent on scintigrams. When the bone scan is doubtful, as often occurs in older subjects, hydroxyproline excretion has been found to be helpful in classifying the patient. When scintigraphy is not available, an elevation of hydroxyproline excretion, together with an elevation of Ca/cr ratio or alkaline phosphatase activity, may pre-date by several months the radiological demonstration of osseous metastases.

2. DOCID:19801 SCORE: 0.00583465533009774
DOCNO: 1561266
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Mammaplasty
QUALIFIER: radiotherapy
AUTHOR: N Handel N
AUTHOR: B Lewinsky B
AUTHOR: J R Waisman JR
AFFILIATION: Breast Center, Van Nuys, Calif. 91405.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Plastic and reconstructive surgery.
COUNTRY: UNITED STATES
TITLE: Reduction mammaplasty following radiation therapy for breast cancer.
PUBDATE: 19920501
This report describes an unusual case in which reduction mammaplasty was performed following radiation therapy for breast cancer. While healing was significantly prolonged (compared with the nonirradiated contralateral breast), the final result was satisfactory from both the functional and the aesthetic standpoint. Women with prior radiation therapy may be considered candidates for reduction mammaplasty. Patients should be warned of the increased risks of wound complications, the likelihood of delayed healing, and the possibility of pigmentation changes in the grafted nipple-areola complex. We elected to transpose the nipple as a full-thickness graft, but consideration also might be given to use of an inferiorly based pedicle flap.

3. DOCID:3022 SCORE: 0.00543369772221965
DOCNO: 1115058
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Mortality
DESCRIPTOR: Radiology
DESCRIPTOR: Specialties, Medical
QUALIFIER: mortality
QUALIFIER: mortality
AUTHOR: G M Matanoski GM
AUTHOR: R Seltser R
AUTHOR: P E Sartwell PE
AUTHOR: E L Diamond EL
AUTHOR: E A Elliott EA
PUBTYPE: Journal Article
JOURNALTITLE: American journal of epidemiology.
COUNTRY: UNITED STATES
TITLE: The current mortality rates of radiologists and other physician specialists: deaths from all causes and from cancer.
PUBDATE: 19750301
The cohort mortality experience of radiologists and other specialists over a 50-year period was examined on the assumption that these groups would differ relative to a presumed decrease in radiation exposure. Radiologists had an excess in all-cause mortality rates compared to the other specialists for all cohorts who entered the Radiological Society of North America before 1940; the excess remained even when the cancer deaths were removed from the rates. These data are consistent with the concept of accelerated aging due to radiation. The cancer mortality rates for radiologists were higher than those of other specialists for an additional decade through 1949. The 1950-1959 cohort had not aged sufficiently to demonstrate the expected peak cancer mortality in the 60-64 year age group. Several hypotheses are presented to suggest reasons for differences in the trends of age-specific cancer mortality by cohorts of entry.

4. DOCID:27348 SCORE: 0.00529479092111998
DOCNO: 11163152
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Oligonucleotide Array Sequence Analysis
QUALIFIER: genetics
QUALIFIER: genetics
AUTHOR: P L Porter PL
AFFILIATION: Divisions of Human Biology and Public Health Sciences, Fred Hutchinson Cancer Research Center, and Department of Pathology, University of Washington Medical Center, 1100 Fairview N, Seattle, Washington 98109, USA. pporter@fhcrc.org
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Current opinion in genetics & development.
COUNTRY: England
TITLE: Molecular markers of tumor initiation and progression.
PUBDATE: 20010201
Of the hundreds of genes and proteins reported to be altered in human cancers, only a few are sufficiently central to warrant translation into diagnostic or therapeutic tools. Three recent developments have the potential to alter radically the discovery of molecular markers: the compendium of human genes; the advent of technologies that provide the means to identify simultaneously several known and unknown genes and proteins; and an appreciation of the critical processes involved in tumor initiation and progression.

5. DOCID:2925 SCORE: 0.00528182734094647
DOCNO: 1247233
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: M E Whitcomb ME
AUTHOR: E Barham E
AUTHOR: A L Goldman AL
AUTHOR: D C Green DC
PUBTYPE: Journal Article
JOURNALTITLE: The American review of respiratory disease.
COUNTRY: UNITED STATES
TITLE: Indications for mediastinoscopy in bronchogenic carcinoma.
PUBDATE: 19760201
In an attempt to formulate indications for mediastinoscopy, the histologic tumor type and the radiographic manifestations of the tumor were correlated with the occurrence of mediastinal node metastases in 121 patients who had potentially resectable bronchogenic carcinoma. Our results demonstrated that mediastinal metastases occur commonly in patients with central lesions irrespective of cell type, but that the histologic tumor type has a definite influence on the frequency of mediastinal involvement in patients with parenchymal masses or peripheral lesions. Our results also demonstrated that the absence of radiographic evidence of mediastinal involvement cannot be given strong consideration when selecting patients for mediastinoscopy, because almost 50 per cent of patients with mediastinal involvement did not have mediastinal widening on the chest roentgenogram. Our results, in conjunction with currently accepted principles governing the management of patients with bronchogenic carcinoma, have allowed us to propose a logical approach for the use of mediastinoscopy in the prethoracotomy evaluation of patients with potentially resectable lung cancer.

6. DOCID:29548 SCORE: 0.00503178589669696
DOCNO: 15582892
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: surgery
AUTHOR: Marc Galiano M
AUTHOR: Fabrice Dugardin F
AUTHOR: François Rozet F
AUTHOR: Xavier Cathelineau X
AUTHOR: Guy Vallancien G
AFFILIATION: Institut mutualiste Montsouris, Université René-Descartes Paris V, 42 boulevard Jourdan, 75674 Paris cedex 14.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Bulletin du cancer.
COUNTRY: France
TITLE: [The surgical management of recurrent urological malignancies after primary ablative therapy]
PUBDATE: 20041101
This literature review highlights the surgical management of recurrent urological malignancies after primary ablative therapy. In particular, recurrent nonseminomatous germ cell tumours (NSGCT) post-chemotherapy, recurrent bladder cancer post-cystectomy, loco-regional recurrence of prostate cancer after radiotherapy, and loco-regional recurrence of renal cell carcinoma after radical nephrectomy. The indications, operative technique, complications and outcomes of each malignancy are discussed.

7. DOCID:2977 SCORE: 0.00480774579347133
DOCNO: 357239
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Cytotoxicity, Immunologic
QUALIFIER: immunology
QUALIFIER: immunology
AUTHOR: H Manabe H
AUTHOR: K Yasumoto K
AUTHOR: M Ohta M
AUTHOR: K Toyohira K
AUTHOR: K Nomoto K
PUBTYPE: Journal Article
JOURNALTITLE: Gann = Gan.
COUNTRY: JAPAN
TITLE: Effect of anticancer therapy of lymphocyte cytotoxicity in lung cancer patients.
PUBDATE: 19770801
Cytotoxicity of lymphocytes against allogeneic target cells of a bronchogenic squamous cell carcinoma was examined by a microcytotoxicity test in lung cancer patients after the various kinds of anticancer treatment. Cytotoxicity in untreated cases at stages I, II, and III was higher than the range of controls, but cytotoxicity in those at stage IV decreased to the range of controls. Tumor resection augmented cytotoxicity in patients at stages II and III, when the assays were carried out 3 weeks after the operation. Local irradiation of tumors augmented cytotoxicity in patients at stages II, III, and IV, when the assays were carried out 1 week after the last irradiation. Immunotherapy with BCG cell-wall skeleton augmented cytotoxicity to a marked degree in patients at stages I, II, III, and IV, when the assays were carried out after 4 months of a continuous treatment. The microcytotoxicity test may be useful for estimating the reactivity of lymphocytes in lung cancer patients in various situations.

8. DOCID:2642 SCORE: 0.00455501242402054
DOCNO: 1227863
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analysis
QUALIFIER: metabolism
QUALIFIER: analysis
QUALIFIER: analysis
QUALIFIER: analysis
AUTHOR: B A Fowler BA
AUTHOR: R C Fay RC
AUTHOR: R L Walter RL
AUTHOR: R D Willis RD
AUTHOR: W F Gutknecht WF
PUBTYPE: Journal Article
JOURNALTITLE: Environmental health perspectives.
COUNTRY: UNITED STATES
TITLE: Levels of toxic metals in marine organisms collected from Southern California coastal waters.
PUBDATE: 19751201
Emission of toxic trace metals into southern California coastal waters has resulted in the extensive accumulation of the elements within marine sediments. The current study was undertaken to evaluate concentrations of trace metals in bottom-dwelling marine fauna collected from two sampling areas. Analyses carried out on muscle samples of the dover sole (Microstomus pacificus) and the crab (Cancer anthonyi) by proton-induced x-ray emission analysis showed considerable concentrations of arsenic and selenium. Samples of gonads, digestive gland, and muscle from the crab Mursia gaudichaudii analyzed by atomic absorption spectroscopy showed elemental concentrations in muscle similar to the crab Cancer anthonyi and much higher metal levels in gonad and digestive gland. These findings suggest the need for further studies concerning the relationship between emission of metals into the marine environment and their abundance in marine fauna.

9. DOCID:11603 SCORE: 0.00454862041274072
DOCNO: 3883219
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: administration & dosage
QUALIFIER: drug therapy
QUALIFIER: pathology
AUTHOR: B A Rodan BA
AUTHOR: F L Cohen FL
AUTHOR: W J Bean WJ
AUTHOR: S N Martyak SN
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Neurosurgery.
COUNTRY: UNITED STATES
TITLE: Fibrous mass complicating epidural morphine infusion.
PUBDATE: 19850101
The benefits of continuous epidural morphine infusion using an implanted pump delivery system to control intractable cancer pain have recently been described. Most articles on this subject relate to dosage, technique, degree of pain relief, and tolerance. There are some anticipated complications of the treatment related to the surgical implantation of the system and drug toxicity. We present a complication presumably related to the epidural catheter. A fibrous reaction that developed around the catheter tip progressed into a mass. This caused a significant displacement of the spinal cord with the development of long tract symptoms. Identification of this abnormality using myelography and computed tomography led to prompt surgical decompression resulting in improvement of the patient's condition.

10. DOCID:31471 SCORE: 0.0042250177937737
DOCNO: 12063827
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Infusions, Intra-Arterial
QUALIFIER: drug therapy
QUALIFIER: administration & dosage
QUALIFIER: drug therapy
AUTHOR: Matthias Lorenz M
AUTHOR: Stefan Heinrich S
AFFILIATION: Department of General and Vascular Surgery, University Hospital of Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany. M.Lorenz@em.uni-frankfurt.de
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Hematology/oncology clinics of North America.
COUNTRY: United States
TITLE: Regional chemotherapy.
PUBDATE: 20020201
Regional chemotherapy is an interesting treatment option in patients with advanced pancreatic cancer but cannot be considered standard treatment, and it should not be performed outside controlled clinical trials. The real value of regional chemotherapy must be evaluated in larger, randomized trials. New drug combinations may reduce the observed side effects and improve tumor response. Gene therapy with p53 and K-ras modulated herpesviruses may become a palliative treatment option and can be administered easily by regional chemotherapy techniques [23].

11. DOCID:31023 SCORE: 0.00422491139190602
DOCNO: 16050939
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug effects
QUALIFIER: pharmacology
AUTHOR: Susan G Lakoski SG
AUTHOR: David M Herrington DM
AFFILIATION: Department of Internal Medicine/Cardiology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Diabetes, obesity & metabolism.
COUNTRY: England
TITLE: Effects of oestrogen receptor-active compounds on lipid metabolism.
PUBDATE: 20050901
Selective estrogen receptor modulators (SERMs) have been used successfully in the treatment of breast cancer and osteoporosis while Tibolone has been used extensively in Europe for the treatment of menopausal symptoms. Limited data is available on the effect of these agents on the cardiovascular system. Traditional and novel lipid markers are valuable in determining patients at increased cardiovascular risk. The purpose of this article is to discuss the mechanism of action of Tamoxifen, Raloxifene and Tibolone and their effects on lipid metabolism.

12. DOCID:22913 SCORE: 0.00422217551554887
DOCNO: 7578386
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: methods
AUTHOR: P Rossi P
AUTHOR: M Bezzi M
AFFILIATION: Department of Radiology, University of Rome La Sapienza, Policlinico Umberto I, Italy.
PUBTYPE: Journal Article
JOURNALTITLE: Current opinion in oncology.
COUNTRY: UNITED STATES
TITLE: Interventional radiology in gastrointestinal neoplasms.
PUBDATE: 19950701
Interventional radiology plays a significant role in different fields of gastrointestinal oncology. Percutaneous techniques can be used to diagnose and stage bile duct and pancreatic cancer. Palliation of esophageal tumors and malignant biliary obstruction may be achieved with interventional techniques, whereas curative attempts are directed mainly towards primary and secondary liver tumors. The therapeutic potential of interventional radiology is still expanding, as are all other forms of minimally invasive therapy. This article reviews the relevant contributions on this subject that have appeared in the past year. The introduction of new techniques is described, and the results of clinical studies are discussed.

13. DOCID:31899 SCORE: 0.0040929514514484
DOCNO: 14702915
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Nurse's Role
QUALIFIER: complications
QUALIFIER: psychology
QUALIFIER: standards
QUALIFIER: standards
QUALIFIER: nursing
AUTHOR: James R Zabora JR
AUTHOR: Matthew J Loscalzo MJ
AUTHOR: Jason Weber J
AFFILIATION: National Catholic School of Social Service, Catholic University of America, 620 Michigan Ave, 102 Shahan Hall, Washington, DC 20064, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Seminars in oncology nursing.
COUNTRY: United States
TITLE: Managing complications in cancer: identifying and responding to the patient's perspective.
PUBDATE: 20031101
OBJECTIVES: To describe psychosocial problems experienced by cancer patients and present assessment tools to evaluate these issues and develop effective management programs. DATA SOURCES: Published literature and clinical experience. CONCLUSION: A screening program may identify patients needing psychologic evaluation and treatment and reduce distress for patients and caregivers. IMPLICATIONS FOR NURSING PRACTICE: Use of screening tools allows critical decisions to be made regarding treatment for patients with high levels of distress, fatigue, and other conditions.

14. DOCID:30694 SCORE: 0.00405447519908823
DOCNO: 16311648
OWNER: NLM
STATUS: In-Process
AUTHOR: Faris Q Alenzi FQ
AFFILIATION: Department of Medical Laboratory Sciences, College of Applied Medical Sciences, King Faisal University, PO Box 2114, Dammam 31451, Kingdom of Saudi Arabia. faris_alenzi@hotmail.com
PUBTYPE: Journal Article
JOURNALTITLE: Saudi medical journal.
COUNTRY: Saudi Arabia
TITLE: Apoptosis and diseases: regulation and clinical relevance.
PUBDATE: 20051101
It is increasingly clear that apoptosis plays a central role in the pathogenesis of several human diseases. For instance, an increase in apoptosis leads to cell loss accompanied by neurodegenerative diseases, whereas we know that genetically determined defects of apoptosis result in deregulated cell proliferation, typical of cancer. Hence, apoptosis may be relevant as therapeutic targets for many human diseases. This article reviews briefly the regulation and the clinical relevance of apoptotic mechanisms in several different human diseases.