0. DOCID:27348 SCORE: 0.00529479092111998
DOCNO: 11163152
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Oligonucleotide Array Sequence Analysis
QUALIFIER: genetics
QUALIFIER: genetics
AUTHOR: P L Porter PL
AFFILIATION: Divisions of Human Biology and Public Health Sciences, Fred Hutchinson Cancer Research Center, and Department of Pathology, University of Washington Medical Center, 1100 Fairview N, Seattle, Washington 98109, USA. pporter@fhcrc.org
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Current opinion in genetics & development.
COUNTRY: England
TITLE: Molecular markers of tumor initiation and progression.
PUBDATE: 20010201
Of the hundreds of genes and proteins reported to be altered in human cancers, only a few are sufficiently central to warrant translation into diagnostic or therapeutic tools. Three recent developments have the potential to alter radically the discovery of molecular markers: the compendium of human genes; the advent of technologies that provide the means to identify simultaneously several known and unknown genes and proteins; and an appreciation of the critical processes involved in tumor initiation and progression.
1. DOCID:29548 SCORE: 0.00503178589669696
DOCNO: 15582892
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: surgery
AUTHOR: Marc Galiano M
AUTHOR: Fabrice Dugardin F
AUTHOR: François Rozet F
AUTHOR: Xavier Cathelineau X
AUTHOR: Guy Vallancien G
AFFILIATION: Institut mutualiste Montsouris, Université René-Descartes Paris V, 42 boulevard Jourdan, 75674 Paris cedex 14.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Bulletin du cancer.
COUNTRY: France
TITLE: [The surgical management of recurrent urological malignancies after primary ablative therapy]
PUBDATE: 20041101
This literature review highlights the surgical management of recurrent urological malignancies after primary ablative therapy. In particular, recurrent nonseminomatous germ cell tumours (NSGCT) post-chemotherapy, recurrent bladder cancer post-cystectomy, loco-regional recurrence of prostate cancer after radiotherapy, and loco-regional recurrence of renal cell carcinoma after radical nephrectomy. The indications, operative technique, complications and outcomes of each malignancy are discussed.
2. DOCID:31471 SCORE: 0.0042250177937737
DOCNO: 12063827
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Infusions, Intra-Arterial
QUALIFIER: drug therapy
QUALIFIER: administration & dosage
QUALIFIER: drug therapy
AUTHOR: Matthias Lorenz M
AUTHOR: Stefan Heinrich S
AFFILIATION: Department of General and Vascular Surgery, University Hospital of Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany. M.Lorenz@em.uni-frankfurt.de
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Hematology/oncology clinics of North America.
COUNTRY: United States
TITLE: Regional chemotherapy.
PUBDATE: 20020201
Regional chemotherapy is an interesting treatment option in patients with advanced pancreatic cancer but cannot be considered standard treatment, and it should not be performed outside controlled clinical trials. The real value of regional chemotherapy must be evaluated in larger, randomized trials. New drug combinations may reduce the observed side effects and improve tumor response. Gene therapy with p53 and K-ras modulated herpesviruses may become a palliative treatment option and can be administered easily by regional chemotherapy techniques [23].
3. DOCID:31023 SCORE: 0.00422491139190602
DOCNO: 16050939
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug effects
QUALIFIER: pharmacology
AUTHOR: Susan G Lakoski SG
AUTHOR: David M Herrington DM
AFFILIATION: Department of Internal Medicine/Cardiology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Diabetes, obesity & metabolism.
COUNTRY: England
TITLE: Effects of oestrogen receptor-active compounds on lipid metabolism.
PUBDATE: 20050901
Selective estrogen receptor modulators (SERMs) have been used successfully in the treatment of breast cancer and osteoporosis while Tibolone has been used extensively in Europe for the treatment of menopausal symptoms. Limited data is available on the effect of these agents on the cardiovascular system. Traditional and novel lipid markers are valuable in determining patients at increased cardiovascular risk. The purpose of this article is to discuss the mechanism of action of Tamoxifen, Raloxifene and Tibolone and their effects on lipid metabolism.
4. DOCID:31899 SCORE: 0.0040929514514484
DOCNO: 14702915
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Nurse's Role
QUALIFIER: complications
QUALIFIER: psychology
QUALIFIER: standards
QUALIFIER: standards
QUALIFIER: nursing
AUTHOR: James R Zabora JR
AUTHOR: Matthew J Loscalzo MJ
AUTHOR: Jason Weber J
AFFILIATION: National Catholic School of Social Service, Catholic University of America, 620 Michigan Ave, 102 Shahan Hall, Washington, DC 20064, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Seminars in oncology nursing.
COUNTRY: United States
TITLE: Managing complications in cancer: identifying and responding to the patient's perspective.
PUBDATE: 20031101
OBJECTIVES: To describe psychosocial problems experienced by cancer patients and present assessment tools to evaluate these issues and develop effective management programs. DATA SOURCES: Published literature and clinical experience. CONCLUSION: A screening program may identify patients needing psychologic evaluation and treatment and reduce distress for patients and caregivers. IMPLICATIONS FOR NURSING PRACTICE: Use of screening tools allows critical decisions to be made regarding treatment for patients with high levels of distress, fatigue, and other conditions.
5. DOCID:30694 SCORE: 0.00405447519908823
DOCNO: 16311648
OWNER: NLM
STATUS: In-Process
AUTHOR: Faris Q Alenzi FQ
AFFILIATION: Department of Medical Laboratory Sciences, College of Applied Medical Sciences, King Faisal University, PO Box 2114, Dammam 31451, Kingdom of Saudi Arabia. faris_alenzi@hotmail.com
PUBTYPE: Journal Article
JOURNALTITLE: Saudi medical journal.
COUNTRY: Saudi Arabia
TITLE: Apoptosis and diseases: regulation and clinical relevance.
PUBDATE: 20051101
It is increasingly clear that apoptosis plays a central role in the pathogenesis of several human diseases. For instance, an increase in apoptosis leads to cell loss accompanied by neurodegenerative diseases, whereas we know that genetically determined defects of apoptosis result in deregulated cell proliferation, typical of cancer. Hence, apoptosis may be relevant as therapeutic targets for many human diseases. This article reviews briefly the regulation and the clinical relevance of apoptotic mechanisms in several different human diseases.
6. DOCID:30599 SCORE: 0.00405447438222321
DOCNO: 15875146
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: methods
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: methods
QUALIFIER: surgery
QUALIFIER: methods
AUTHOR: J R Siewert JR
AUTHOR: H Bartels H
AUTHOR: H J Stein HJ
AFFILIATION: Chirurgische Klinik und Poliklinik, Klinikum rechts der Isar der TU München.
PUBTYPE: Journal Article
JOURNALTITLE: Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen.
COUNTRY: Germany
TITLE: [Abdomino-right-thoracic esophagectomy with intrathoracic anastomosis in Barrett's cancer]
PUBDATE: 20050601
The modified technique of abdomino-right-thoracic esophagectomy (the Lewis-Tanner approach) is increasingly being favoured as the surgical procedure of choice in patients with resectable adenocarcinoma of the distal esophagus, so-called Barrett's cancer. The technical details of this procedure and the reconstruction of gastrointestinal continuity using a gastric tube with high intrathoracic anastomosis are illustrated, as they have proved useful in our own practice during recent years.
7. DOCID:27979 SCORE: 0.00371945336633542
DOCNO: 11357148
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
AUTHOR: J Peto J
AFFILIATION: Institute of Cancer Research, Sutton, Surrey SM2 5NG, and London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Nature.
COUNTRY: England
TITLE: Cancer epidemiology in the last century and the next decade.
PUBDATE: 20010501
By the early 1980s, epidemiologists had identified many important causes of cancer. They had also proposed the 'multi-stage' model of cancer, although none of the hypothesized events in human carcinogenesis had then been identified. The remarkable advances in cell and molecular biology over the past two decades have transformed the scope and methods of cancer epidemiology. There have been a few new discoveries based purely on traditional methods, and many long-suspected minor risks have been estimated more precisely. But modern epidemiological studies often depend on genetic, biochemical or viral assays that had not been developed 20 years ago.
8. DOCID:27133 SCORE: 0.00366672228581337
DOCNO: 11383248
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Orchiectomy
DESCRIPTOR: Prostatectomy
QUALIFIER: psychology
QUALIFIER: surgery
AUTHOR: P S Marschke PS
AFFILIATION: Department of Urology, Johns Hopkins School of Medicine, JHOC-4th Floor Urology, 601 N Caroline St, Baltimore, MD 21287-0850, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Seminars in oncology nursing.
COUNTRY: United States
TITLE: The role of surgery in the treatment of prostate cancer.
PUBDATE: 20010501
OBJECTIVES: To describe the role of surgery in the treatment of organ-confined prostate cancer and advanced prostate cancer. DATA SOURCES: Journals, textbooks, and personal communication. CONCLUSIONS: Radical prostatectomy plays a possible role in curing those patients with disease confined to the prostate. Bilateral orchiectomy plays a palliative role for patients with advanced disease. IMPLICATIONS FOR NURSING PRACTICE: This article provides nurses with the knowledge needed to teach patients about how the surgery is performed, the associated complications, and the likelihood of cancer control.
9. DOCID:26525 SCORE: 0.00336212470366599
DOCNO: 9840972
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Proportional Hazards Models
QUALIFIER: methods
AUTHOR: S Y Lee SY
AUTHOR: R A Wolfe RA
AFFILIATION: Department of Applied Statistics, Sejong University, Seoul, Korea. leesy@cs.sejong.ac.kr
PUBTYPE: Journal Article
JOURNALTITLE: Biometrics.
COUNTRY: UNITED STATES
TITLE: A simple test for independent censoring under the proportional hazards model.
PUBDATE: 19980901
A simple method for testing the assumption of independent censoring is developed using a Cox proportional hazards regression model with a time-dependent covariate. This method involves further follow-up of a subset of lost-to-follow-up censored subjects. An adjusted estimator of the survivor function is obtained for the dependent censoring model under a proportional hazards alternative. The proposed procedure is applied to an example of a clinical trial for lung cancer and a simulation study is given for investigating the power of the proposed test.
10. DOCID:26961 SCORE: 0.00336198254970419
DOCNO: 10235353
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Neoplasms, Second Primary
DESCRIPTOR: Pulmonary Artery
DESCRIPTOR: Stents
QUALIFIER: therapy
QUALIFIER: complications
QUALIFIER: complications
QUALIFIER: complications
QUALIFIER: etiology
QUALIFIER: complications
AUTHOR: J D Urschel JD
AFFILIATION: Department of Thoracic Surgical Oncology, Roswell Park Cancer Institute, Buffalo, New York 14263-0001, USA.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Journal of laparoendoscopic & advanced surgical techniques. Part A.
COUNTRY: UNITED STATES
TITLE: Delayed massive hemoptysis after expandable bronchial stent placement.
PUBDATE: 19990401
Patients with lung cancer often develop airway obstruction that necessitates palliative bronchoscopic interventions. Expandable metal stents are increasingly used for this indication. We report a case of fatal massive hemoptysis that occurred 1 week after uneventful bronchial stent placement. Previous treatment with external-beam radiotherapy, brachytherapy, and photodynamic therapy probably contributed to pulmonary artery-bronchial fistulization in this patient. This complication should be kept in mind when considering expandable airway stent insertion in heavily pretreated lung cancer patients.
11. DOCID:26284 SCORE: 0.00327135035490082
DOCNO: 11445022
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Quality of Life
QUALIFIER: diagnosis
QUALIFIER: prevention & control
QUALIFIER: complications
QUALIFIER: complications
AUTHOR: S Samdani S
AUTHOR: E Lachmann E
AUTHOR: W Nagler W
AFFILIATION: Department of Physical Medicine and Rehabilitation, New York Presbyterian Hospital, New York, New York, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Journal of women's health & gender-based medicine.
COUNTRY: United States
TITLE: Unilateral extremity swelling in female patients with cancer.
PUBDATE: 20010501
Unilateral extremity swelling may be secondary to two major causes in female patients with cancer, deep venous thrombosis (DVT) and lymphedema. In women of all ages, DVT is high on the differential diagnosis list for unilateral extremity swelling. However, in women with an underlying malignancy, DVT and lymphedema must both be considered. Appropriate diagnosis and treatment are necessary to improve the quality of life and function of the female patient with cancer.
12. DOCID:28854 SCORE: 0.00325436450950068
DOCNO: 12568049
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Attitude of Health Personnel
DESCRIPTOR: Organizational Innovation
DESCRIPTOR: Social Change
QUALIFIER: organization & administration
AUTHOR: Rose Gollop R
PUBTYPE: Journal Article
JOURNALTITLE: The Health service journal.
COUNTRY: England
TITLE: Modernisation. Fear of flying.
PUBDATE: 20030101
Interviews with senior managers and clinicians involved in the national booking programme and cancer care collaborative found that scepticism, particularly among doctors, was a barrier to implementing change. Regular feedback and clear evidence of change emerged as key factors in persuading sceptics of the benefits of different ways of working. Getting sceptics on board can be a long process and time spent talking to them is not wasted. Consultants' support is key for endorsing change.
13. DOCID:27443 SCORE: 0.00317754990602775
DOCNO: 11327501
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Diagnosis, Computer-Assisted
DESCRIPTOR: Neural Networks (Computer)
QUALIFIER: classification
QUALIFIER: genetics
AUTHOR: F Azuaje F
AFFILIATION: Artificial Intelligence Group and Centre for Health Informatics, Trinity College, Dublin, Ireland.
PUBTYPE: Journal Article
JOURNALTITLE: IEEE transactions on bio-medical engineering.
COUNTRY: United States
TITLE: A computational neural approach to support the discovery of gene function and classes of cancer.
PUBDATE: 20010301
Advances in molecular classification of tumours may play a central role in cancer treatment. Here, a novel approach to genome expression pattern interpretation is described and applied to the recognition of B-cell malignancies as a test set. Using cDNA microarrays data generated by a previous study, a neural network model known as simplified fuzzy ARTMAP is able to identify normal and diffuse large B-cell lymphoma (DLBCL) patients. Furthermore, it discovers the distinction between patients with molecularly distinct forms of DLBCL without previous knowledge of those subtypes.
14. DOCID:27984 SCORE: 0.00314914074348814
DOCNO: 10839530
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: physiology
QUALIFIER: physiology
AUTHOR: S Kersten S
AUTHOR: B Desvergne B
AUTHOR: W Wahli W
AFFILIATION: Institut de Biologie Animale, Université de Lausanne, Switzerland.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Nature.
COUNTRY: ENGLAND
TITLE: Roles of PPARs in health and disease.
PUBDATE: 20000501
In developed societies, chronic diseases such as diabetes, obesity, atherosclerosis and cancer are responsible for most deaths. These ailments have complex causes involving genetic, environmental and nutritional factors. There is evidence that a group of closely related nuclear receptors, called peroxisome proliferator-activated receptors (PPARs), may be involved in these diseases. This, together with the fact that PPAR activity can be modulated by drugs such as thiazolidinediones and fibrates, has instigated a huge research effort into PPARs. Here we present the latest developments in the PPAR field, with particular emphasis on the physiological function of PPARs during various nutritional states, and the possible role of PPARs in several chronic diseases.