0. DOCID:25917 SCORE: 0.00643209196377112
DOCNO: 10553409
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: administration & dosage
QUALIFIER: drug therapy
AUTHOR: T Kubota T
AFFILIATION: Dept. of Surgery, School of Medicine, Keio University.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Gan to kagaku ryoho. Cancer & chemotherapy.
COUNTRY: JAPAN
TITLE: [Theoretical basis for low-dose CDDP/5-FU therapy]
PUBDATE: 19991001
The theoretical basis for low-dose cisplatin (CDDP)/5-fluorouracil (5-FU) therapy is rather clear. CDDP can inhibit methionine-uptake into tumor cells and cause depletion of folate cofactors including 5-CH3FH4 and FH4, which are essential for the formation of a ternary complex with thymidylate synthetase and 5-fluorodeoxyuridine, an active metabolite of 5-FU. The literature on this mechanism are reviewed herein, and the methionine-dependency of human cancer xenografts and the modulation of 5-FU-cytotoxicity through methionine-depletion are reported.

1. DOCID:26082 SCORE: 0.00500332748170083
DOCNO: 10228355
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: complications
QUALIFIER: etiology
AUTHOR: M Malerba M
AUTHOR: S Cavaliere S
AUTHOR: A Marengoni A
AUTHOR: A Politi A
AUTHOR: A Radaeli A
AUTHOR: V Grassi V
AFFILIATION: Cattedra di Medicina Interna I, Università, Brescia. medresp@master.cci.unibs.it
PUBTYPE: Case Reports
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Recenti progressi in medicina.
COUNTRY: ITALY
TITLE: [Tracheal stenosis due to metastatic adenopathic compression from breast carcinoma]
PUBDATE: 19990301
Paratracheal lymph-nodal metastases secondary of breast cancer aren't frequent in this kind of cancer. Here is described the case of a 76-years-old woman come to our note for ingravescent dyspnoea caused by metastatic adenopathy compression of the tracheal lumen. After excluding other treatments, a tracheal stent is put on. The obstruction gets better right away, the initial severe respiratory symptoms are improved and the ventilation is almost normal.

2. DOCID:30701 SCORE: 0.00439186965148416
DOCNO: 16050939
OWNER: NLM
STATUS: In-Process
AUTHOR: Susan G Lakoski SG
AUTHOR: David M Herrington DM
AFFILIATION: Department of Internal Medicine/Cardiology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.
PUBTYPE: Journal Article
JOURNALTITLE: Diabetes, obesity & metabolism.
COUNTRY: England
TITLE: Effects of oestrogen receptor-active compounds on lipid metabolism.
PUBDATE: 20050901
Selective estrogen receptor modulators (SERMs) have been used successfully in the treatment of breast cancer and osteoporosis while Tibolone has been used extensively in Europe for the treatment of menopausal symptoms. Limited data is available on the effect of these agents on the cardiovascular system. Traditional and novel lipid markers are valuable in determining patients at increased cardiovascular risk. The purpose of this article is to discuss the mechanism of action of Tamoxifen, Raloxifene and Tibolone and their effects on lipid metabolism.

3. DOCID:26389 SCORE: 0.00410638193822204
DOCNO: 11189780
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: organization & administration
QUALIFIER: rehabilitation
QUALIFIER: organization & administration
QUALIFIER: organization & administration
QUALIFIER: organization & administration
AUTHOR: H H Bartsch HH
AUTHOR: H Delbrück H
AUTHOR: P Kruck P
AUTHOR: L Schmid L
AFFILIATION: Klinik für Tumorbiologie an der Universität Freiburg. baha@tumorbio.uni-freiburg.de
PUBTYPE: Journal Article
JOURNALTITLE: Die Rehabilitation.
COUNTRY: Germany
TITLE: [Process quality in oncologic rehabilitation. Viewpoint of the Professional Committee of Rehabilitation, After-care and Social Medicine of the German Cancer Society]
PUBDATE: 20001201
The article concerns itself with the issue of process quality in inpatient institutions for oncological rehabilitation and expresses the viewpoint of the German Cancer Society's Section for Rehabilitation, Aftercare and Social Medicine (ARNS). Standards for the organization of patients' access to the rehabilitation clinic, for the design of oncological-rehabilitational diagnostics, for the formation of therapeutic strategies and the rehabilitative services offered will be described.

4. DOCID:30601 SCORE: 0.00380951243867117
DOCNO: 15753432
OWNER: NLM
STATUS: In-Process
AUTHOR: C M Roe CM
AUTHOR: M I Behrens MI
AUTHOR: C Xiong C
AUTHOR: J P Miller JP
AUTHOR: J C Morris JC
AFFILIATION: Division of Biostatistics, Washington University School of Medicine, 660 South Euclid Avenue, Box 8067, St. Louis, MO 63110, USA. cathyr@wubios.wustl.edu
PUBTYPE: Journal Article
JOURNALTITLE: Neurology.
COUNTRY: United States
TITLE: Alzheimer disease and cancer.
PUBDATE: 20050301
Cross-sectional studies raise the possibility of protective relationships between, or a common mechanism underlying, the development of dementia of the Alzheimer type (DAT) and cancer. Using a prospective longitudinal design, the authors found that the risk of developing cancer is less among participants with DAT vs nondemented participants (p < 0.001) and that the risk of developing DAT may be less for participants with a history of cancer (p = 0.060).

5. DOCID:27504 SCORE: 0.00364734543053272
DOCNO: 9750487
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: classification
QUALIFIER: pathology
QUALIFIER: classification
QUALIFIER: pathology
AUTHOR: A Sakamoto A
AUTHOR: Y Terado Y
AFFILIATION: Department of Pathology, School of Medicine, Kyorin University.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Nippon rinsho. Japanese journal of clinical medicine.
COUNTRY: JAPAN
TITLE: [Histological classification of prostatic cancer]
PUBDATE: 19980801
Histological classification of prostatic cancer with a special focus on adenocarcinoma was reviewed according to "General Rule for Clinical and Pathological Studies on Prostatic Cancer (The 2nd Edition, 1992) published by Japanese Urological Association and The Japanese Society of Pathology. The points of the classification are as follows; (1) adenocarcinoma is separated into 3 categories, namely, well, moderately and poorly differentiated types, by structural features. (2) nuclear grading does not commit for making a subclassification of prostatic adenocarcinoma. The other types of primary malignancies are rare in the prostate. Prostatic intraepithelial neoplasia should be discussed in the further revision of the classification.

6. DOCID:31533 SCORE: 0.00363629843150245
DOCNO: 14755362
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Surgery, Plastic
QUALIFIER: complications
QUALIFIER: pathology
QUALIFIER: surgery
AUTHOR: M Wollny M
AUTHOR: P Schmidt-Rhode P
AFFILIATION: Frauenklinik Barmbek-Finkenau, Hamburg. Maximilian.Wollny@t-online.de
PUBTYPE: Journal Article
JOURNALTITLE: Zentralblatt für Gynäkologie.
COUNTRY: Germany
TITLE: [Plastic surgery of defects of the thoracic wall]
PUBDATE: 20031201
Defects of the thoracic wall are mostly due to a malignant disease of the mammary gland. Radiotherapy is one of the essential methods of treating cancer of the breast in addition to primary surgery. If, after surgery, healing occurs by secondary intention or if there is a local recurrence or tumour formation in the thoracic wall due to irradiation, the body's reserves of soft parts are often exhausted and the adjacent tissue has been additionally damaged by the irradiation. General principles of treatment in the management of such problems are presented by means of several case reports.

7. DOCID:24182 SCORE: 0.00348814230076061
DOCNO: 14731833
OWNER: NLM
STATUS: PubMed-not-MEDLINE
AUTHOR: J C Litherland JC
AFFILIATION: West of Scotland Breast Screening Service and Glasgow Royal Infirmary, Glasgow.
PUBTYPE: Journal Article
JOURNALTITLE: Breast (Edinburgh, Scotland)
COUNTRY: Scotland
TITLE: The effects of HRT on screening mammography.
PUBDATE: 20000601
The effects of hormone replacement therapy on screening for breast cancer by mammography are reviewed. There is a decline in specificity in screen mammography for women over the age of 50 taking oral preparations, The use of HRT also reduces the sensitivity of breast screening by regular mammography.

8. DOCID:27386 SCORE: 0.00347736407770712
DOCNO: 10669049
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pharmacology
QUALIFIER: pharmacology
QUALIFIER: metabolism
QUALIFIER: pharmacology
QUALIFIER: pharmacology
AUTHOR: K Takao K
AUTHOR: S Takai S
AUTHOR: T Ishihara T
AUTHOR: S Mita S
AUTHOR: M Miyazaki M
AFFILIATION: Department of Pharmacology, Osaka Medical College, Takatsuki, Japan.
PUBTYPE: Journal Article
JOURNALTITLE: Japanese journal of pharmacology.
COUNTRY: JAPAN
TITLE: Inhibition of human chymase by suramin.
PUBDATE: 19991201
Chymase is a chymotrypsin-like protease localized in mast cells in complexes with heparin. In the present study, we demonstrated that suramin, a hexasulfonated naphthylurea used as an anti-cancer drug, inhibits the activity of purified human chymase in vitro. The inhibition was ionic-strength-dependent. It was observed that suramin competed with heparin-Sepharose gel for binding to chymase and the inhibition of chymase activity by suramin was partially impaired by heparin. Our results show that suramin may become a prototype of a new type of chymase inhibitor because of its unique character.

9. DOCID:29300 SCORE: 0.00336887184239295
DOCNO: 14750313
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Nurse's Role
DESCRIPTOR: Oncologic Nursing
QUALIFIER: nursing
AUTHOR: Kumi Endo K
AFFILIATION: Dept. of Nursing, Shizuoka Cancer Center, 1007 Shimonagakubo, Nagaizumi-machi, Suntou-gun, Shizuoka 411-8777, Japan.
PUBTYPE: Journal Article
JOURNALTITLE: Gan to kagaku ryoho. Cancer & chemotherapy.
COUNTRY: Japan
TITLE: [Role of oncologic nurses in cancer chemotherapy]
PUBDATE: 20040101
The field of cancer chemotherapy requires specialized knowledge and skills, and nurses working in this field undergo specialized training. Oncologic nurses have a large role in cancer chemotherapy and demonstrate superior practical ability while also serving as counselors to patients and as promoters and coordinators of team-based medical care. They also work to carry out education and research on nursing in the field of cancer chemotherapy.

10. DOCID:27411 SCORE: 0.00330798590716117
DOCNO: 10938655
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
AUTHOR: H R Metelmann HR
AFFILIATION: Klinik für Mund-, Kiefer- und Gesichtschirurgie/Plastische Operationen, Greifswald, Deutschland.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Mund-, Kiefer- und Gesichtschirurgie : MKG.
COUNTRY: GERMANY
TITLE: [Chemotherapy and radiochemotherapy in tumors of the head-neck area]
PUBDATE: 20000501
Standard curative therapy in head and neck cancer, especially in oral cavity carcinoma, consists, so far, of surgery. Until today, chemotherapy using standard drugs has failed to be effective beyond controlling cancer manifestations and palliation of symptoms. The introduction of chemotherapy and radiotherapy as adjuvant treatment, however, may improve overall survival and curative options. A multicentric randomized trial, initiated by DOSAK, has compared results after radical surgery alone with results of combined preoperative radio-chemotherapy followed by radical surgery. The life table analysis substantiated improved survival rates in the group of patients whose treatment included chemotherapy and radiation.

11. DOCID:27218 SCORE: 0.00330785630544737
DOCNO: 9563228
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Ampulla of Vater
DESCRIPTOR: Common Bile Duct Neoplasms
DESCRIPTOR: Cystadenoma, Mucinous
DESCRIPTOR: Neoplasms, Multiple Primary
DESCRIPTOR: Ovarian Neoplasms
DESCRIPTOR: Pregnancy Complications, Neoplastic
AUTHOR: T K Choudhury TK
AUTHOR: A Sen A
AFFILIATION: Department of General Surgery, Institute of Post Graduate Medical Education and Research, Calcutta.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology.
COUNTRY: INDIA
TITLE: Periampullary carcinoma with bilateral ovarian cystadenoma in pregnancy.
PUBDATE: 19980401
We report a 30-year-old woman with periampullary cancer and a large left ovarian cystadenoma presenting during pregnancy with features of duodenal obstruction. She had a right benign ovarian tumor removed a year back. She delivered an intrauterine-growth-retarded live baby. Laparotomy in the postpartum period revealed an unresectable periampullary growth with hepatic metastasis and a left ovarian cystadenoma. The ovarian tumor was removed and a palliative gastrojejunostomy performed.

12. DOCID:30146 SCORE: 0.00326613042647226
DOCNO: 16115232
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: R J Kurman RJ
AUTHOR: J D Seidman JD
AUTHOR: I-M Shih IM
AFFILIATION: Department of Pathology, Washington Hospital Center, Washington, DC, USA. rkurman@jhmi.edu
PUBTYPE: Journal Article
JOURNALTITLE: Histopathology.
COUNTRY: England
TITLE: Serous borderline tumours of the ovary.
PUBDATE: 20050901
Serous borderline tumours of the ovaryIn this Expert Opinion we have invited articles from two leading groups, to discuss serous borderline tumours (serous tumours of low malignant potential) of the ovary from their own perspectives. Controversy remains over heterogeneity within this group of tumours and their relationship to ovarian cancer. Our authors discuss the histopathological classification of these tumours in relation to morphological appearances, molecular and clinical data. The significance of a micropapillary pattern is discussed, and issues related to extra-ovarian implants.

13. DOCID:29915 SCORE: 0.00322543441612116
DOCNO: 12530232
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Magnetic Resonance Imaging
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: Lawrence E Ginsberg LE
AFFILIATION: Department of Diagnostic Radiology, University of Texas MD Anderson Cancer Center, Box 57, 1515 Holcombe Boulevard, Houston, TX 77030, USA. lginsberg@di.mdacc.tmc.edu
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Magnetic resonance imaging clinics of North America.
COUNTRY: United States
TITLE: MR imaging of perineural tumor spread.
PUBDATE: 20020801
Perineural tumor spread (PNS) is a common and potentially devastating complication of head and neck cancer. Because perineural tumor spread may be asymptomatic, the radiologist plays a critical role in the evaluation of the head and neck cancer patient. Although PNS may be seen on CT, MR imaging is far more sensitive and is the imaging modality of choice in the evaluation of perineural tumor spread.

14. DOCID:31921 SCORE: 0.00309951516172687
DOCNO: 12797851
AUTHOR: Rodney J Baber RJ
AUTHOR: Justine L O'Hara JL
AUTHOR: Frances M Boyle FM
AFFILIATION: Department of Obstetrics and Gynaecology, University of Sydney, Sydney, NSW 2006, Australia. rbaber@mail.usyd.edu.au
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: The Medical journal of Australia.
COUNTRY: Australia
TITLE: Hormone replacement therapy: to use or not to use?
PUBDATE: 20030601
The main indication for hormone replacement therapy (HRT) is to control menopausal symptoms and improve quality of life. Ideally, withdrawal of HRT should be attempted after 4-5 years of therapy. HRT reduces fracture risk and remains appropriate therapy for osteoporosis, particularly in women with symptoms. HRT is not appropriate for primary or secondary cardioprotection. HRT leads to a small increase in breast cancer incidence, which increases with duration of therapy and age. HRT increases the risk of thromboembolism. Patient management and therapy should be reviewed annually with risk-benefit counselling.