0. DOCID:16627 SCORE: 0.00364689064027003
DOCNO: 1597271
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: B Caniels B
AUTHOR: W Hammans W
AFFILIATION: Institut für Klinische Genetik und Zytologie, Akademisches Lehrkrankenhaus GH Essen.
PUBTYPE: Journal Article
JOURNALTITLE: Geburtshilfe und Frauenheilkunde.
COUNTRY: GERMANY
TITLE: [CIN and pregnancy, a 20-year retrospect]
PUBDATE: 19920301
This is a report on CIN associated with pregnancy in a review over the last 20 years. Biological tumour behaviour, diagnostic problems and therapy are discussed in 100 cases of preinvasive and invasive lesions of the cervix. It is pointed out that low acceptance of early detection measures in association with late pregnancy planning may contribute to an increase of invasive cancer in pregnancy.

1. DOCID:17896 SCORE: 0.00336528407586771
DOCNO: 2278511
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: chemical synthesis
QUALIFIER: chemical synthesis
QUALIFIER: chemical synthesis
QUALIFIER: drug effects
AUTHOR: S Erber S
AUTHOR: H Birnböck H
AUTHOR: E von Angerer E
AFFILIATION: Institut für Pharmazie, Universität Regensburg.
PUBTYPE: Journal Article
JOURNALTITLE: Archiv der Pharmazie.
COUNTRY: GERMANY
TITLE: Synthesis and biological properties of a 1-(6-aziridinylhexyl)-2-phenylindole, a potential fluorescence label for estrogen receptors.
PUBDATE: 19900801
2-Phenylindole derivative 8, linked to aziridine by a hexamethylene spacer group, was synthesized and tested. It binds to the estrogen receptor with an RBA-value of 4.0 (estradiol = 100). In vitro, it shows a selective cytostatic activity in hormone-dependent MCF-7 breast cancer cells (41% T/C at 10(-6) M). In vivo, it exerts a strong estrogenic effect. The binding to the estrogen receptor is largely reversible.

2. DOCID:18909 SCORE: 0.00334229796545248
DOCNO: 2195801
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Neoplasm Seeding
DESCRIPTOR: Tissue Donors
QUALIFIER: pathology
QUALIFIER: physiopathology
QUALIFIER: pathology
AUTHOR: K Lucius K
AUTHOR: H Oesterwitz H
AUTHOR: P Müller P
AUTHOR: W Blank W
AUTHOR: G May G
AFFILIATION: Urologische Klinik, Krankenhauses in Friedrichshain, Berlin.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Zeitschrift für Urologie und Nephrologie.
COUNTRY: GERMANY, EAST
TITLE: [Transplantation of the kidneys of donors with cancer--personal experiences and review of the literature]
PUBDATE: 19900201
From 1980 to 1988 more than 1,549 organ donors were harvested, 125 of them (8%) died from cancer--116 brain tumors and 9 donors with extracerebral cancer. In 3 donors suffering from extracerebral cancer 5 kidneys were transplanted. All transplants functioned well without tumor signs up to 21 months after grafting. However, because of tumor recurrence in nearly 50% of the cases described in the literature generally organs from donors suffering from extracerebral cancer should not transplanted if possible.

3. DOCID:18923 SCORE: 0.00334229256669497
DOCNO: 8222585
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: therapy
AUTHOR: I D Hay ID
AUTHOR: G G Klee GG
AFFILIATION: Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Clinics in laboratory medicine.
COUNTRY: UNITED STATES
TITLE: Thyroid cancer diagnosis and management.
PUBDATE: 19930901
This article provides an overview of the classification of thyroid carcinoma into well-differentiated forms (papillary and follicular) as well as the rare Hurthle cell, medullary, and anaplastic forms. The characteristics, relative frequency, and mortality rates of each form of thyroid cancer are summarized. The roles of history, physical examination, blood tests, such as thyroid function test, thyroglobulin (htg), calcitonin and CEA, radionuclide and ultrasound imaging, and fine-needle aspirates are outlined for the diagnosis and management of thyroid cancer. An algorithmic diagram of the monitoring procedures for long-term management of various forms of thyroid cancer is presented.

4. DOCID:18684 SCORE: 0.00333181396548
DOCNO: 2183730
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Mass Screening
DESCRIPTOR: Occult Blood
DESCRIPTOR: Sigmoidoscopy
QUALIFIER: prevention & control
AUTHOR: D A Lieberman DA
AFFILIATION: Department of Medicine, Oregon Health Sciences University, Portland.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Archives of internal medicine.
COUNTRY: UNITED STATES
TITLE: Colon cancer screening. The dilemma of positive screening tests.
PUBDATE: 19900401
Despite doubts about the benefits of colon cancer screening, sigmoidoscopy and fecal occult blood tests are now often performed by clinicians who must then deal with positive test results. The purpose of this literature review is to examine potential strategies for dealing with positive screening test results. If positive results are obtained, current data support the use of colonoscopy as the single most effective diagnostic strategy. Exceptions include situations that reduce the predictive value of the screening test. Several important areas of controversy are highlighted that need to be assessed in subsequent studies.

5. DOCID:19490 SCORE: 0.00323472611975139
DOCNO: 1591325
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: physiology
QUALIFIER: mortality
AUTHOR: S K Van den Eeden SK
AUTHOR: G D Friedman GD
AFFILIATION: Division of Research, Kaiser Permanente Medical Care Program, Northern California Region, Oakland 94611-5463.
PUBTYPE: Journal Article
JOURNALTITLE: Epidemiology (Cambridge, Mass.)
COUNTRY: UNITED STATES
TITLE: Forced expiratory volume (1 second) and lung cancer incidence and mortality.
PUBDATE: 19920501
We evaluated the relation between forced expiratory volume in 1 second (FEV1) and lung cancer incidence and mortality among members of the Kaiser Permanente Medical Care Program who took a multiphasic health checkup. FEV1 was inversely related to risk of lung cancer among former and current smokers, but not related among never-smokers. We observed a decreased risk of lung cancer mortality only in the higher quintiles of FEV1 in current smokers among men, but not in women. FEV1 appears to be associated with lung cancer as a physiologic marker for smoking-induced pulmonary damage.

6. DOCID:18839 SCORE: 0.00318728658850078
DOCNO: 2106647
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Military Personnel
QUALIFIER: epidemiology
AUTHOR: W K Ruffin WK
AFFILIATION: Department of General Surgery, Naval Hospital, Millington, Tennessee.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Military medicine.
COUNTRY: UNITED STATES
TITLE: Colon cancer in the active duty population.
PUBDATE: 19900201
Of the 140,000 cases of colorectal cancer anticipated this year, approximately 2% to 6% will occur in patients less than 40 years old. Data regarding colon cancer in this age group applies directly to the similarly aged active duty population. The problem is illustrated by two case histories. A review of the literature indicates that patients of this age group may have a worse prognosis, not due to age per se, but likely due to a combination of an advanced stage at diagnosis and a higher percentage of poorly differentiated or mucin-producing tumors. Early diagnosis remains essential for improved survival.

7. DOCID:19931 SCORE: 0.0031872512502203
DOCNO: 2297720
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analysis
QUALIFIER: immunology
QUALIFIER: analysis
QUALIFIER: therapy
AUTHOR: H M Blottière HM
AUTHOR: J Y Douillard JY
AUTHOR: H Koprowski H
AUTHOR: Z Steplewski Z
AFFILIATION: Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania 19104.
PUBTYPE: Journal Article
JOURNALTITLE: Cancer research.
COUNTRY: UNITED STATES
TITLE: Immunoglobulin class and immunoglobulin G subclass analysis of human anti-mouse antibody response during monoclonal antibody treatment of cancer patients.
PUBDATE: 19900201
The immune response against murine IgG2a immunoglobulin was studied in 42 gastrointestinal cancer patients treated with mouse monoclonal antibodies. IgM, IgA, and all 4 IgG subclasses directed against mouse immunoglobulin were studied. Thirty of 42 patients developed an anti-mouse response of IgG isotype, often associated with IgM and IgA specific for mouse monoclonal antibodies circulating in serum. Patients first developed an IgM response, followed by IgA and IgG. IgG1 was found to be the most frequently expressed isotype, followed by IgG2 and IgG3. IgG4 was detected in only 6 patients.

8. DOCID:19697 SCORE: 0.00299632264836582
DOCNO: 1742450
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: prevention & control
QUALIFIER: methods
QUALIFIER: prevention & control
AUTHOR: S G Self SG
AFFILIATION: Fred Hutchinson Cancer Research Center, Seattle, Washington 98104.
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
PUBTYPE: Randomized Controlled Trial
JOURNALTITLE: Biometrics.
COUNTRY: UNITED STATES
TITLE: An adaptive weighted log-rank test with application to cancer prevention and screening trials.
PUBDATE: 19910901
A class of adaptive weighted log-rank statistics is described where the vector of weights is chosen in a data-dependent way from a family of "smooth" weight vectors. A parametric family of weight vectors is identified which includes most shapes of weighting vectors that will be near optimal in many cancer prevention and screening trials. This family of weight vectors is used in an application of the proposed method to data from a breast cancer screening trial. Results from a small simulation study comparing the power of the adaptive statistic to that of the unweighted log-rank statistic are presented.

9. DOCID:19053 SCORE: 0.00291877897514867
DOCNO: 1930480
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Registries
QUALIFIER: epidemiology
AUTHOR: B S Menéndez BS
AUTHOR: S Blum S
AFFILIATION: Lehman College, City University of New York.
PUBTYPE: Journal Article
JOURNALTITLE: Boletín de la Asociación Médica de Puerto Rico.
COUNTRY: PUERTO RICO
TITLE: The Puerto Rico and New York State tumor registries: problems associated with the use of cancer incidence data in migrant studies.
PUBDATE: 19910601
This paper discusses specific problems pertaining to compatibility of data between the Puerto Rico and New York State tumor registries, which is applicable to other studies comparing cancer incidence rates from two distinct tumor registries. Discrepancies in the data between the two tumor registries were due to differences in quality control, under and overreporting of cancer cases, reliability indicators, and case criteria. A study comparing stomach cancer incidence rates between Puerto Rico and Puerto Rican migrants to New York City provided the foundation for this investigation.

10. DOCID:19167 SCORE: 0.00279978910259983
DOCNO: 1696521
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Palliative Care
QUALIFIER: methods
QUALIFIER: surgery
AUTHOR: P L Birnbaum PL
AUTHOR: C D Mercer CD
AFFILIATION: Department of Surgery, Hotel Dieu Hospital, Queen's University, Kingston, Ont.
PUBTYPE: Journal Article
JOURNALTITLE: Canadian journal of surgery. Journal canadien de chirurgie.
COUNTRY: CANADA
TITLE: Laser fulguration for palliation of rectal tumours.
PUBDATE: 19900801
Palliative therapy for rectal carcinoma includes control of bleeding, tenesmus, mucous discharge, obstruction and pain. These local symptoms can cause serious morbidity for patients with locally advanced or metastatic rectal cancer. As an alternative to surgical resection for palliation, the authors applied endoscopic laser fulguration in 15 patients with rectal tumours; 14 experienced immediate relief of symptoms. At 6.4 months' follow-up, two patients had recurrent tenesmus and two required a colostomy. A high degree of patient acceptance makes laser fulguration for rectal tumours an important modality, for palliation; however, control of tenesmus may be temporary.

11. DOCID:17542 SCORE: 0.00262141204723921
DOCNO: 1683303
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Carcinoma, Squamous Cell
DESCRIPTOR: Uterine Cervical Neoplasms
AUTHOR: J C Schink JC
AUTHOR: J R Lurain JR
AFFILIATION: Department of Obstetrics and Gynecology, Northwestern University Medical School, Chicago, IL 60611.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics.
COUNTRY: IRELAND
TITLE: Microinvasive cervix cancer.
PUBDATE: 19910901
Microinvasive cervix cancer (Stage Ia) is the earliest stage of squamous carcinoma, and has a 98% 5-year survival. This article reviews risk factors, etiology, and diagnosis of this disease. The important prognostic factors for treatment planning are depth of invasion, lateral extent of invasive tumor, and lymphvascular space invasion. Conservative management is appropriate in selected cases with the goal of preserving fertility.

12. DOCID:18584 SCORE: 0.00261121338131525
DOCNO: 2000664
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: epidemiology
QUALIFIER: epidemiology
QUALIFIER: epidemiology
AUTHOR: L B Svendsen LB
AUTHOR: S Bülow S
AUTHOR: A Mellemgaard A
AFFILIATION: Bispebjerg Hospital, København, kirurgisk afdeling F.
PUBTYPE: Journal Article
JOURNALTITLE: Ugeskrift for laeger.
COUNTRY: DENMARK
TITLE: [Metachronous colorectal cancer]
PUBDATE: 19910201
The occurrence of metachronous colo-rectal cancer was investigated in 903 patients under the age of 40 years at the time of diagnosis of the primary cancer. A constant frequency of metachronous colo-rectal cancers was found and a cumulated incidence of 30% after an observation period of 41 years. Metachronous cancer of the colon was encountered most frequently in the right half of the colon regardless of the site of the primary cancer. On the basis of the above mentioned results, a life-long follow-up programme is recommended, consisting of regular examination for blood in the faeces and colonoscopy.

13. DOCID:18141 SCORE: 0.0025983160834135
DOCNO: 1874825
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Cluster Analysis
QUALIFIER: classification
QUALIFIER: classification
AUTHOR: L Hodes L
AUTHOR: A Feldman A
AFFILIATION: National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892.
PUBTYPE: Journal Article
JOURNALTITLE: Journal of chemical information and computer sciences.
COUNTRY: UNITED STATES
TITLE: Clustering a large number of compounds. 3. The limits of classification.
PUBDATE: 19910501
Clustering is normally used to group items that are similar. In this application of obtaining a diverse sample from the 230,000 compounds in the National Cancer Institute Repository, we cluster to select compounds that are different from the rest, to optimize screening for new leads. With these constraints, our approach yielded many singleton clusters. We can interpret these results as evidence for a limit to classification, contrary to the customary view of chemistry as a study of classes of compounds.

14. DOCID:18166 SCORE: 0.00259831455882692
DOCNO: 7525754
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Palliative Care
DESCRIPTOR: State Government
QUALIFIER: therapy
AUTHOR: J L Dahl JL
AFFILIATION: Department of Pharmacology, University of Wisconsin-Madison Medical School.
PUBTYPE: Journal Article
JOURNALTITLE: Journal of pain and symptom management.
COUNTRY: UNITED STATES
TITLE: State cancer pain initiatives.
PUBDATE: 19930801
Interest and participation in state cancer pain initiatives have grown rapidly in the past 5 yr. Of signal importance to these state efforts is the fact that several national groups have made relief of cancer pain a priority. State cancer pain initiatives will play a key role in disseminating basic pain-management information, in changing practice and ultimately in evaluating the effectiveness of cancer pain control efforts. They are dedicated to making relief of cancer pain a reality. That is a challenge that will occupy them for many years to come.