0. DOCID:31263 SCORE: 0.00238417567254218
DOCNO: 15546933
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Chromosome Aberrations
DESCRIPTOR: Database Management Systems
DESCRIPTOR: Software
DESCRIPTOR: User-Computer Interface
QUALIFIER: methods
QUALIFIER: methods
QUALIFIER: methods
AUTHOR: Bernhard Hiller B
AUTHOR: Jutta Bradtke J
AUTHOR: Harald Balz H
AUTHOR: Harald Rieder H
AFFILIATION: Institut für Klinische Genetik der Phillipps-Universität Marburg, Bahnhofstrasse 7, 35037 Marburg, Germany.
PUBTYPE: Journal Article
JOURNALTITLE: Bioinformatics (Oxford, England)
COUNTRY: England
TITLE: CyDAS: a cytogenetic data analysis system.
PUBDATE: 20050401
For statistical analyses in cancer cytogenetics, the genomic changes encoded by the karyotype must be translated into numerical codes. We developed a program, which extracts chromosomal gains and losses as well as breakpoints from the karyotype. The changes are compiled in tables according to the chromosome bands involved and/or depicted in projection to the respective chromosome ideogram. The data are ready to be integrated into further statistical analyses. The program may be run as desktop or Internet application.

1. DOCID:30637 SCORE: 0.00235693702923702
DOCNO: 15043429
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: isolation & purification
QUALIFIER: chemistry
QUALIFIER: isolation & purification
QUALIFIER: chemistry
AUTHOR: Ahmed A Hussein AA
AUTHOR: Icela Barberena I
AUTHOR: Todd L Capson TL
AUTHOR: Thomas A Kursar TA
AUTHOR: Phyllis D Coley PD
AUTHOR: Pablo N Solis PN
AUTHOR: Mahabir P Gupta MP
AFFILIATION: Centro de Investigaciones Farmacognósticas de la Flora Panameña (CIFLORPAN), Facultad de Farmacia, Universidad de Panamá, Apartado 10767, Estafeta Universitaria, Panama, Republic of Panama.
PUBTYPE: Journal Article
JOURNALTITLE: Journal of natural products.
COUNTRY: United States
TITLE: New cytotoxic naphthopyrane derivatives from Adenaria floribunda.
PUBDATE: 20040301
Bioassay-guided fractionation of an EtOAc/MeOH extract of Adenaria floribunda young leaves using MCF-7, H-460, and SF-268 cancer cell lines yielded four new active compounds named adenaflorins A-D (1-4). Their chemical structures were determined by spectroscopic means. Adenaflorin A (1) was the most cytotoxic.

2. DOCID:31576 SCORE: 0.00200878131097522
DOCNO: 12154411
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Disease Models, Animal
QUALIFIER: genetics
AUTHOR: Laurie Jackson-Grusby L
AFFILIATION: Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, Massachusetts, MA 02142, USA. jackson@wi.mit.edu
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Oncogene.
COUNTRY: England
TITLE: Modeling cancer in mice.
PUBDATE: 20020801
The laboratory mouse is one of the most powerful tools for both gene discovery and validation in cancer genetics. Recent technological advances in engineering the mouse genome with chromosome translocations, latent alleles, and tissue-specific and temporally regulated mutations have provided more exacting models of human disease. The marriage of mouse tumor models with rapidly evolving methods to profile genetic and epigenetic alterations in tumors, and to finely map genetic modifier loci, will continue to provide insight into the key pathways leading to tumorigenesis. These discoveries hold great promise for identifying relevant drug targets for treating human cancer.

3. DOCID:31916 SCORE: 0.00196574033651935
DOCNO: 12850768
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pharmacology
QUALIFIER: blood supply
QUALIFIER: physiopathology
AUTHOR: Andréas Bikfalvi A
AFFILIATION: Laboratoire des mécanismes moléculaires de l'angiogenèse (Inserm E0113), Université Bordeaux I, avenue des Facultés, 33405 Talence. a.bikfalvi@croissance.u-bordeaux.fr
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Bulletin du cancer.
COUNTRY: France
TITLE: [Tumor angiogenesis]
PUBDATE: 20030501
Recent advances in the understanding of the molecular control of angiogenesis have shown that this process is essential for tumor development and spread. The identification of a great many of ligands, receptors or intracellular signalling molecules have allowed to unravel some of the regulatory loops involved. Especially noteworthy is the fact that developmental regulators seem now to play a role in tumor angiogenesis. Furthermore, these studies have allowed to identify novel therapeutic targets and to develop novel molecules and strategies for cancer therapy. This indicates that tumor angiogenesis is at present a major focus of cancer research.

4. DOCID:29838 SCORE: 0.00192500618177907
DOCNO: 16382046
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Gene Expression Regulation, Neoplastic
QUALIFIER: metabolism
QUALIFIER: metabolism
AUTHOR: Padhma Ranganathan P
AUTHOR: Vivek M Rangnekar VM
AFFILIATION: Graduate Center for Toxicology, University of Kentucky, Lexington, Kentucky 40536, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Annals of the New York Academy of Sciences.
COUNTRY: United States
TITLE: Regulation of cancer cell survival by Par-4.
PUBDATE: 20051101
Prostate apoptosis response-4 (Par-4) is a unique pro-apoptotic protein that selectively induces apoptosis in cancer cells. Moreover, Par-4 sensitizes cells to the action of diverse apoptotic stimuli and causes tumor regression. This review discusses the prominent structural and functional features of Par-4 and the multiple levels of regulation of its apoptotic function, all of which can be utilized to develop targeted cancer therapy.

5. DOCID:30212 SCORE: 0.00192497894555582
DOCNO: 15242372
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Cystectomy
QUALIFIER: surgery
QUALIFIER: diagnosis
QUALIFIER: surgery
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: Steven Sorscher S
AUTHOR: Rezwan Islam R
AUTHOR: Albert Mason A
AFFILIATION: Oncology Department, Marshfield Clinic-Wausau Center, Wausau Hospital, WI 54401, USA. sorscher.steven@marshfieldclinic.org
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: International journal of urology : official journal of the Japanese Urological Association.
COUNTRY: Australia
TITLE: Urethral 'recurrence' found 14 years after radical cystectomy.
PUBDATE: 20040701
We report a case of transitional cell urethral cancer diagnosed 14 years after radical cystectomy. Traditionally, in the postcystectomy setting, these cancers have been referred to as 'recurrences'. We review the biological models for the oncogenesis of these cancers and propose that they are typically a result of a field cancerization effect, rather than being derived from the same clone responsible for the original urothelial tumor.

6. DOCID:30863 SCORE: 0.00191810858950621
DOCNO: 12512167
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Coal Mining
DESCRIPTOR: Pneumoconiosis
DESCRIPTOR: Silicon Dioxide
DESCRIPTOR: Silicosis
AUTHOR: Robert Cohen R
AUTHOR: Valerie Velho V
AFFILIATION: Rush University Medical College, Division of Occupational Medicine and Pulmonary Medicine/Critical Care, Cook County Hospital, Chicago, IL, USA. bobcohen@uic.edu
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Clinics in chest medicine.
COUNTRY: United States
TITLE: Update on respiratory disease from coal mine and silica dust.
PUBDATE: 20021201
Coal mine and silica dust cause significant respiratory disease in spite of modern dust control regulations. Susceptible individuals in exposed populations may develop fibrosing lung disease, obstructive airways disease, including chronic bronchitis and emphysema, or lung cancer. A careful occupational history that elicits exposure to respiratory hazards is the cornerstone of an accurate diagnosis. Treatment involves removal from exposure, supportive care, pulmonary rehabilitation, and when disabling disease is present, assistance obtaining compensation.

7. DOCID:30562 SCORE: 0.00189765023123266
DOCNO: 11978520
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: economics
AUTHOR: W B van den Hout WB
AUTHOR: M van den Brink M
AUTHOR: A M Stiggelbout AM
AUTHOR: C J H van de Velde CJ
AUTHOR: J Kievit J
AFFILIATION: Department of Medical Decision Making, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, The Netherlands. w.b.van_den_hout@lumc.edu
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: European journal of cancer (Oxford, England : 1990)
COUNTRY: England
TITLE: Cost-effectiveness analysis of colorectal cancer treatments.
PUBDATE: 20020501
A concise overview is provided of the methodology of cost-effectiveness analyses, followed by a survey of published CEAs of colorectal cancer treatments. To gain credibility, the methodology applied in CEAs must be further improved. Costs are rarely estimated from the societal perspective, and little is known about how colorectal patients value their treatment and health.

8. DOCID:30709 SCORE: 0.00187491735273851
DOCNO: 15837615
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pharmacology
QUALIFIER: pharmacology
QUALIFIER: antagonists & inhibitors
AUTHOR: Stevan R Hubbard SR
AFFILIATION: Structural Biology Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA. hubbard@saturn.med.nyu.edu <hubbard@saturn.med.nyu.edu>
PUBTYPE: Journal Article
JOURNALTITLE: Cancer cell.
COUNTRY: United States
TITLE: EGF receptor inhibition: attacks on multiple fronts.
PUBDATE: 20050401
The epidermal growth factor receptor (EGFR) drives tumor growth in a subset of human epithelial carcinomas. A crystallographic study by Li et al. in this issue of Cancer Cell provides the molecular basis for inhibition of EGFR by cetuximab (Erbitux), a monoclonal antibody that has been approved by the Food and Drug Administration as a therapeutic for advanced-stage colorectal cancers. Cetuximab targets one of the ligand binding domains of EGFR, thus preventing ligand activation of the receptor.

9. DOCID:30165 SCORE: 0.00186111037048404
DOCNO: 15565555
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Hemostasis
QUALIFIER: blood
QUALIFIER: surgery
AUTHOR: Jakob Lykke J
AUTHOR: Hans Jørgen Nielsen HJ
AFFILIATION: Surgical Immunology Laboratory, Department of Surgical Gastroenterology, Hvidovre University Hospital, Copenhagen, Denmark. jly@dadlnet.dk
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Journal of surgical oncology.
COUNTRY: United States
TITLE: Haemostatic alterations in colorectal cancer: perspectives for future treatment.
PUBDATE: 20041201
The role of the haemostatic system in colorectal cancer (CRC) is reviewed. Correlations between the activation of the haemostatic system and overall survival have been suggested. Experimental studies indicate that the haemostatic system plays a key role in growth, invasion and dissemination of tumour cells, and in tumour related angiogenesis. Additional activation by the surgical trauma and postoperative infections are discussed. Finally, anti-cancer modalities directed against regulation of the haemostatic system in CRC are considered.

10. DOCID:31110 SCORE: 0.0018546563509736
DOCNO: 12652803
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Gene Expression
QUALIFIER: analysis
QUALIFIER: genetics
QUALIFIER: diagnosis
QUALIFIER: analysis
QUALIFIER: genetics
AUTHOR: Yuji Hinoda Y
AFFILIATION: Division of Clinical Laboratory, Yamaguchi University Hospital.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Rinsho byori. The Japanese journal of clinical pathology.
COUNTRY: Japan
TITLE: [Cytokine gene]
PUBDATE: 20021101
The most important aspect of cytokine gene expression in cancer is paraneoplastic syndrome. Paraneoplastic syndrome presents symptoms and signs characteristic of substances that tumors produce, some of which have been revealed to be cytokine. Detection of cytokine gene expression in paraneoplastic syndrome is important not only for diagnosis but for monitoring of anti-cytokine therapy that is expected to be rapidly developed. Proper diagnosis and treatment of paraneoplastic syndrome are also important for improving the QOL of cancer patients. In this context, recent advancement of anti-cytokine monoclonal antibody therapy is expected to aid treatment.

11. DOCID:30588 SCORE: 0.00175651825967069
DOCNO: 16341083
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: genetics
QUALIFIER: enzymology
AUTHOR: Andreas G Bader AG
AUTHOR: Sohye Kang S
AUTHOR: Li Zhao L
AUTHOR: Peter K Vogt PK
AFFILIATION: Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Nature reviews. Cancer.
COUNTRY: England
TITLE: Oncogenic PI3K deregulates transcription and translation.
PUBDATE: 20051201
There have long been indications of a role for PI3K (phosphatidylinositol 3-kinase) in cancer pathogenesis. Experimental data document a requirement for deregulation of both transcription and translation in PI3K-mediated oncogenic transformation. The recent discoveries of cancer-specific mutations in PIK3CA, the gene that encodes the catalytic subunit p110alpha of PI3K, have heightened the interest in the oncogenic potential of this lipid kinase and have made p110alpha an ideal drug target.

12. DOCID:30469 SCORE: 0.0017565164936533
DOCNO: 16372483
OWNER: NLM
STATUS: In-Process
AUTHOR: C Faivre-Finn C
AUTHOR: L W Lee LW
AUTHOR: P Lorigan P
AUTHOR: C West C
AUTHOR: N Thatcher N
AFFILIATION: Clinical Oncology Department, Christie Hospital NHS Trust, Manchester, UK. corinne.finn@christie-tr.nwest.nhs.uk
PUBTYPE: Journal Article
JOURNALTITLE: Clinical oncology (Royal College of Radiologists (Great Britain))
COUNTRY: England
TITLE: Thoracic radiotherapy for limited-stage small-cell lung cancer: controversies and future developments.
PUBDATE: 20051201
Thoracic radiotherapy has an established role in the management of limited-disease small-cell lung cancer (LD SCLC). However, essential questions relating to the optimisation of thoracic radiotherapy remain unanswered, including volume of irradiation, optimal total dose, fractionation, timing and sequencing of radiation. This review highlights the need for well-designed multi-national trials aimed at the optimisation and standardisation of radiotherapy for LD SCLC.

13. DOCID:31238 SCORE: 0.00175650448066678
DOCNO: 15965963
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: etiology
QUALIFIER: physiopathology
AUTHOR: Mario Caputi M
AUTHOR: Giuseppe Russo G
AUTHOR: Vincenzo Esposito V
AUTHOR: Alessandro Mancini A
AUTHOR: Antonio Giordano A
AFFILIATION: Department of Cardio-Thoracic Sciences, II University of Naples, Naples, Italy.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Journal of cellular physiology.
COUNTRY: United States
TITLE: Role of cell-cycle regulators in lung cancer.
PUBDATE: 20051201
Lung cancer is the leading cause of cancer death worldwide. Histologically, 80% of lung cancers are classified as non-small-cell lung cancer (NSCLC), and the remaining 20% as small-cell lung cancer (SCLC). Lung carcinoma is the result of molecular changes in the cell, resulting in the deregulation of pathways controlling normal cellular growth, differentiation, and apoptosis. This review summarizes some of the most recent findings about the role of cell-cycle proteins in lung cancer pathogenesis and progression.

14. DOCID:30850 SCORE: 0.0017272750358192
DOCNO: 12846356
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Lymph Node Excision
QUALIFIER: etiology
QUALIFIER: secondary
QUALIFIER: adverse effects
QUALIFIER: secondary
AUTHOR: P Vereecken P
AUTHOR: A Mathieu A
AUTHOR: M Laporte M
AUTHOR: M Petein M
AUTHOR: M Heenen M
AFFILIATION: Department of Dermatology, Erasme Hospital, Free University of Brussels, Brussels, Belgium.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: International journal of clinical practice.
COUNTRY: England
TITLE: Spread of melanoma after lymphatic drainage: relaunching the debate.
PUBDATE: 20030601
Secondary lymphoedema of the leg can result in disruption of lymphatic vessels following lymph node surgery. Evidence supports the use of complex decongestive physiotherapy (CDP) in such cases, despite the possibility of tumour recurrence due to this therapy in cancer patients. We present the case of a 52-year-old woman who developed in-transit metastases and systemic evaluable disease one month after starting CDP for secondary lymphoedema of the leg.