Analysis
Supplement – Biclustering Analysis of Predicted Receptor Interactome
1. Biclustering on the predicted
receptor interactome
Biclustering
is a data mining technique that allows simultaneous clustering of rows and
columns in a matrix [1]. Given a set of m
rows and n columns (i.e., an m*n matrix), biclustering algorithms
generate biclusters defined as a subset of rows that exhibit similar behaviour
across a subset of columns, or vice versa. On our receptor interactome, a
certain bicluster module contains a subset of human proteins that exhibit
similar interaction behaviour across a subset of human receptors.
We
used the biclustering software toolbox BicAT [2] to bicluster the receptor interactome graph. BicAT
is a graphical user interface software for the analysis of gene expression
data. It provides five biclustering and two standard clustering algorithms. The
algorithm we used was the Iterative Signature Algorithm (ISA) which searches
for submatrices representing fixed points [3]. Our graph was first transformed from weighted graph
into a binary graph (by setting all existing edges’ weight to 1). The fixed
points that this algorithm looks for are the interaction edges (which take on the
value ‘1’ in our input graph when using the ISA method). About 40 biclusters
were detected and their sizes range from ~180 genes to ~10 genes covered.
Each derived module (bicluster) represents a list of similarly interacting partners. to possible biological pathways. We found that many of the detected biclusters relate to specific biological pathways [4]. For example, a large number of proteins in several clusters participate in apoptotic pathways, including NOTCH, TNF, TLR3 in one bicluster and TGFbR2, TNF, BMP, FAS in another bicluster are receptors of different apoptotic pathways. Some examples of ligands/molecules on the protein side inducing or inhibiting apoptosis are DAF, STAT, MAPK, PAK, AKT. In general, we observed that proteins in biclusters included both the receptor as well as ligand and signaling cascade partners. For example, in clusters including the TNF and FAS pathways, many of the proteins were ligands of the TNF pathway eg. TRAF2, TRADD, FADD. In another cluster, NOTCH and LRP5 were found on the receptor side with the protein side partners being those that participate in either the NOTCH or the Wnt/LRP pathways. The involvement of most of the molecules in a cluster in a common pathway validates the basis of the formation of these local modules.
A detailed list of modules (biclusters) is available as Table S6.1. Specific modules that are most relevant to the paper are shown below in graphical representation.
2. Visualization of specific biclusters of significance to the results
presented in the paper
Biclusters can also be represented as subgraphs
in the predicted receptor interactome. Below we show examples of visualized
biclusters of relevance to the interactions discussed in more detail in the
paper.
Visualization of the
biggest bicluster: The
following figure is the visualization of the biggest bicluster we detected. It
includes 109 gene nodes with 1962 PPI edges between receptors and their
partners. This is a very dense subgraph with closely connected Type I
receptors. This bicluster includes EGFR and HCK.
|
Figure
1
The visualization of the biggest bicluster in the
predicted receptor interactome. Green represents type I receptors. All
other human gene nodes are red. |
Visualization of biclusters related to rhodopsin: Rhodopsin appeared as a member in four of the
biclusters detected. Since there was overlap between the proteins in these
clusters, we only show the largest bicluster containing rhodopsin here (Fig.
S6.2). It includes 40 nodes and 53 edges.
|
Figure
2
The
visualization of one bicluster relating to |
Biclusters
related to Chemokine ligands: There
are more than ten biclusters that include chemokines. One example is shown
below.
|
Figure
3
The
visualization of a bicluster relating to chemokine genes in the predicted
receptor interactome. Green refers to type I receptors and blue
represents GPCRs. All other other human gene nodes (including ligands) are
red. |
TGF1
related bicluster: TGF1
related to two overlapping biclusters. The bigger bicluster contains 110 nodes and
288 edges, shown in Fig. S6.4.
|
Figure
4
The
visualization of the bicluster relating to TGF1 in the predicted receptor interactome. Green refers
to type I receptors. All other human gene nodes are red. |
3. Detected modules from biclustering on our human membrane receptor
interactome
You can download the following table in a
separate file as well. (download)
Table 1
Modules
from biclustering: The bicluster moduls are listed. Each module contains three lines. It starts
with a line of two numbers, which means the size of their related human
proteins and membrane receptor proteins. Then the following line contains the
human proteins (gene name) in this module and the third line includes the
related membrane receptors (gene name).
108 47 PTPN11 SPTBN1
PTPN6 HCK EPHA5 PTPRS ERBB4 NEO1 GRB14 DDR1 KDR CIT PRKD2 TYRO3 ABL1 AKT3
CSF1R TGFBR2 JAK2 PRKD3 RASA1 ARHGEF2 FGFR1 EPHA2 INSRR LCK GRB7 TEK AKT1
PTPRJ MERTK GRB10 FGFR3 EPHA4 FGD1 ABL2 PTK2B ERBB3 CRKL ERBB2 PTK7 EDD1 SHC1
MARK1 PRKD1 EGFR FGFR4 RYK ROR1 JAK1 EPHA8 PDGFRA TYK2 EPHA1 EPHB1 NTRK2
ROCK1 TGFB3 FYN DDR2 PTPRF LATS1 ADRBK2 NTRK1 FES FRK DGKD FLT1 HBEGF MET
HRMT1L1 ADRBK1 SRC PTPRD CSK EPHB4 TIE1 EPHB2 ROR2 PTPRG FLT4 EPHA3 NET1
SNF1LK LYN SNF1LK2 YES1 PDGFRB TNK2 PTPRU NTRK3 AXL CBL INSR GAB1 SYK ROCK2
ALK IGF1R PTPN1 KIT PTK2 FER TRIO LATS2 PTPRC MARK2 EPHB3 MERTK FGFR3
EPHB4 PDGFRB FLT1 PTPRF ROR1 EPHB3 EPHB2 EPHA2 PTPRD IGF1R TEK PTPRS EPHA3
TYRO3 EPHA8 RYK EPHA5 EPHB6 PDGFRA EPHB1 KDR EPHA4 PTK7 PTPRG INSR PTPRU FLT4
FGFR4 EPHA1 CSF1R ERBB3 EGFR KIT DDR1 ALK NTRK2 ROR2 NTRK3 DDR2 MET PTPRJ
ERBB4 FGFR1 AXL ERBB2 112 28 THBD CD83 LIFR
HRMT1L2 LCP2 SPINK5 GLMN IL15 IL1R1 LILRB2 IFNA2 GNLY IFNW1 CD40LG CSF1R
TNFSF10 IRAK2 IL17F MMP25 C1QG KNG1 TXNDC THBS1 IL7 IL1RAP ADM TACSTD2 CD86
LTBR IL22 SERPINA1 IL2RB LOC153561 STAT5A CD72 LY75 COL1A2 DAF PTGS2 LILRB3
IFNGR1 IL8 CD40 NOTCH1 C1QB FN1 IL7R IL10RA MAP7 WDR33 C7 IL1RN INHBA IL4R
LTB4R C1QR1 IL16 CSF2RB ITGB2 IL1RL1 CD97 TNFRSF14 IFNAR2 SON HLA-DRB5 CX3CR1
LILRB1 DBNL IL2RG TIMP3 C3 CD8A TNFRSF7 HLA-DMA C1QA VWF IFNGR2 IL6ST PROS1
TXNDC4 IRF4 PLAT IL10RB ANK2 ITGB1 TCIRG1 CD1D CD14 C4A CD58 BST1 F11R LY96
C1R APOL3 CD69 IL6R SCYE1 PLAUR GNB2L1 TLR4 CTGF LAT AOAH IFNAR1 STAT1 CD164
TLR6 MCP NALP12 GRAP2 HLA-DMB CD40 TLR3
NOTCH1 IFNAR2 LILRB3 IL6ST PROCR IFNGR2 TLR4 IL10RB IL2RG TNFRSF7 PLAUR IL6R
ITGB2 ITGB1 F2RL2 IL2RB CSF1R IL1R1 C1QR1 IL4R TNFRSF14 IFNGR1 IL7R F3 IFNAR1
CD97 176 13 DAPK1 MAPK1
RHOC DAPK2 STK4 MAP2K1 WNK2 DUSP10 MAP3K3 DUSP6 MELK TRAF3 RIPK2 PRKCB1 EPHA5
PAK1 DAB2 NEK6 PRKCH STK38L TRIB1 CDK3 PLK1 STK25 PIM1 RAF1 EIF2AK2 TRAF5
TGFBR2 MAP3K5 MAPK8 ACVR1 MAPK10 CDKN3 MAP4K1 FNTA ICK MAP3K7IP1 MAP2K3
SMURF1 BRAF ERN1 DAPK3 ACVR1B RPS6KA1 MKNK2 CDK4 SRPK2 PRKG1 GOLGA5 GRK5
RPS6KA5 MAPK13 MAP2K6 AKT1 PRKAA1 VRK2 DUSP4 HIPK1 WNK1 NPR1 ARAF MAP3K12
PCTK2 CAMK4 SMURF2 CLK3 PCTK3 NPR2 MAP3K4 TRAF6 CDK6 CDC2L5 MAPKAPK3 MAPK7
CDC2L1 MAP3K2 ULK1 CDK5 PRKCZ CHUK MAP3K7 PASK RPS6KA4 ILK CSNK1D MAPK9 PTEN
DAPP1 DUSP16 SGK GRK6 MAPKAPK2 MARK3 BUB1 PAK4 CCNB1 PRKCI STK17B CSNK1G3
PRKACB BUB1B GSK3B MAP2K5 PINK1 PCTK1 MAP2K4 GRK4 STK38 RPS6KB1 CAMK2D
RPS6KA2 CSNK2A2 PRKCA TGFBR1 ACVR2A DYRK2 LIMK1 MAP4K4 CSNK1A1 PRKCE CLK2
TRAF4 IRAK1 PIM2 CSNK1G2 SMAD1 PFTK1 MAPKAPK5 SMAD5 ACVRL1 BMPR2 CAMK1 IRAK3
PRKCD MAPK14 PKN1 MAPK12 RIPK1 MAP4K3 SGK3 SNRPB MKNK1 BMPR1A HIPK2 CLK1
STK17A MAP4K2 PRKACA DAXX PDPK1 SNF1LK SNF1LK2 RPS6KB2 MAP3K10 PKN2 EIF3S2
RPS6KA3 CSNK1E CAMK2G STK3 STK24 CDC7 MAP4K5 CHEK1 MAPK6 DCAMKL2 TGFBRAP1
PRKCQ PAK2 PLK2 CDC42 RHOG DUSP2 CDC25B MARK2 TGFBR2
TNFRSF10A BMPR2 FAS BMPR1A TNFRSF10B TGFBR1 ACVRL1 TNFRSF11B TNFRSF25 ACVR1B
ACVR1 TNFRSF21 78 17 S100B CCL24
CCR4 CCR7 CCL27 CCL16 MAPRE2 CCR5 CCL26 LSP1 IFNG CCR2 AFP CCL11 CCL19 CCL28
IL8RA CXCL2 CCL18 TNF DRD2 CXCL12 PROK2 CXCL6 TXK CCL5 TNFAIP6 ITGAL CCL23
AHSG CCL4 GNA14 LOC146909 ATP1A3 CCL20 ADA CCL13 IL8 PPBP CXCL3 XCL1 CXCL1
IGFBP1 CXCR3 CCL7 CCL1 IL16 FPRL1 CCR6 STAT3 CCL21 CD97 IL10 SAA2 CD52 MIF
CSRP3 CXCL5 IL13 CCL8 CXCR4 CCL2 ARRB1 CCKAR DEFB4 GRIN1 CXCR6 CCL15 IL11
CCL17 IFNB1 CCL3 GZMK CCL25 CCR1 CXCL10 NAALADL2 CCL3L3 BDKRB2 CCR2
IL8RA CCBP2 ADORA2A IL8RB FPRL1 CCR4 FY EDG3 CXCR3 CCR5 CCR6 PRLR CCR8 CCR1
CCR3 105 11 DAPK1 ZNF207
STK4 ATF4 NFKB1 RTN3 RIPK2 TPT1 AP2M1 TNFRSF1A PBP ADAM9 CALM1 TMEM66 NOL5A
TGFB1 RAF1 PSME3 TNFRSF21 FXYD5 MAP3K5 H3F3B EIF4A1 HSPCA PPP2R1A CASP10 BRAF
DAPK3 CCT3 TRAF2 SLC3A2 HDLBP LDHA DEDD GPI KIAA0174 K-ALPHA-1 CTNNA1 WNK1
ACTB ATP5A1 DDX5 CRADD ADAM15 VIM LTB HNRPH1 PRKCZ PKM2 CHUK 2-Sep CFLAR
IKBKG IKBKB HADHB FLJ22555 MAPKAPK2 TNFRSF10B NONO UBC ARPC5 CSNK2A1 SPOP
TNFRSF11B EIF3S6IP STX12 ROCK1 PRKCA CASP7 IGFBP3 LTA PRKCE TRAF4 CASP8 VCP
CIRBP YWHAE WBP2 DCTN2 DAP FADD HSPA8 CD74 RIPK1 RPL4 PIP5K2B FAS TEGT HIPK2
STK17A ENO1 HSPCB WARS FUS STK3 YARS GNB2L1 TXNIP ALDOA MALT1 SNX17 RAB7
TNFRSF10A SFRS2 TRADD TNFRSF10A UNC5B
FAS TNFRSF10B TNFRSF1A DGCR2 NGFR TNFRSF11B TFG TNFRSF25 TNFRSF21 151 7 HSPA5 ELAC2
PCDH18 VEGF CD63 NLGN1 LTBP2 DAG1 SPOCK1 PRDX4 SNTB1 FBN1 SERPINA3 DGCR2
SHMT2 PVRL1 MCAM JAG2 PCSK7 NEO1 MIB2 PTPNS1 PCDHA6 NRP2 THBS4 COL14A1 PRCP
SGCE ALPL FXYD5 SYT1 ACSL4 SPG7 P4HA1 ENPP2 CTSH PECAM1 KITLG MRPS22 PTGS1
HYAL1 VGLL4 MGAT1 GAK LSAMP SIDT2 MMP12 PKD1 ROBO4 FAT TNFRSF12A SEMA3B ABCD4
SLIT2 VNN1 SYT5 NRXN3 COL4A6 PPAP2A PVR EFNB1 ITGAL LAMC2 COMP PSAP FURIN
BMP5 SEMA4D PMM2 INHBB POLR3D GPNMB SEMA5A PPGB STIM1 STS MAN2B1 EI24 EDIL3
COL7A1 HYOU1 LAMA4 KAL1 ADRM1 TGFB2 GDF15 COL6A2 SYT4 SYT6 NID2 LAMC1 AMFR
BMP4 SULF1 ADAM12 NCAM1 THBS3 ADAM23 TOR1A ACHE AGRN CD24 NDST1 LIPA COL16A1
EFEMP1 MMP2 SPOCK2 MGP GALC PKD2 LAMA1 ITGA4 LAMB3 SSR4 PON2 SORT1 SEMA4F LPL
TMED10 SYTL3 PCDH1 NUP210 NLGN2 BMP1 GSTT1 BTD LAMB2 SPP1 FMOD BMP2 C1R SYTL2
SPINT2 GPX4 SDC4 RPLP2 NPC2 ELN ASAH1 FKBP9 SMPDL3B SERPING1 SLC8A1 SORL1
C22orf5 LARGE RARG ACADVL DCBLD2 ACE TNFRSF12A NRXN3
NEO1 NRP2 NRXN1 ENG NRP1 51 18 S100B CCR7
MAPRE2 LSP1 IFNG CCL11 CCL19 IL8RA CXCL2 DRD2 GNA15 CXCL12 PROK2 CXCL6 CCL5
ITGAL CCL23 AHSG CCL4 IL8RB CCL20 BDKRB2 IL8RA
F2R LRRN6D CCBP2 ADORA2A IL8RB FPRL1 FY EDG3 CXCR3 CCR6 PRLR FPR1 C3AR1 CCR1
OPRK1 ADORA1 83 9 DAPK1 ZNF207
STK4 NFKB1 TRAF3 RIPK2 PAK1 TNFRSF1A ADAM9 NOL5A TGFB1 PIM1 RAF1 TNFRSF21
EIF2AK2 MAP3K5 TNFSF10 HSPCA BAG4 CASP10 BRAF DAPK3 TRAF2 DEDD HIPK3 AKT1
PRKAA1 WNK1 DDX5 CRADD TNFRSF25 TNFSF11 VIM CDC2L1 LTB HNRPH1 CASP8AP2 PRKCZ
CHUK CFLAR IKBKG IKBKB MAPKAPK2 TNFRSF10B NONO STK17B CSNK2A1 TNFRSF11B DEDD2
ROCK1 PRKCA CASP7 IGFBP3 PRKCE TRAF4 CASP8 WBP2 PFTK1 DAP FADD HSPA8 NGFR
RIPK1 MYD88 PIP5K2B FAS HIPK2 SLAMF7 STK17A UNC5B CTSS RPS6KA3 STK3 YARS
TNFSF12 TAP2 TNFSF15 MALT1 RAB7 TNFRSF10A SFRS2 FASLG TRADD TNFRSF10A UNC5B
FAS TNFRSF10B TNFRSF1A NGFR TNFRSF11B TNFRSF25 TNFRSF21 123 6 CXCL9 NOV
HLA-DQA1 CD83 DKK1 PRNP LEPR NFKB1 FBN1 ANGPT1 PPARD FALZ ARMC8 IL15 JAG2
NFATC3 LILRB2 RBPSUH NRP2 SERPINF1 TNFRSF19 NOTCH3 CSE1L SEMA3C TNFSF10 EDNRB
CD3D SEMA4B VDR ANGPT2 NR2F2 PLXNB1 MFNG CTNNB1 CCNC IL15RA EIF2B4 MAML1 RXRA
LEF1 TXNDC DNASE2 EXT1 EP300 EFNB1 ITGAL CREG1 SEMA4D PF4 DVL2 TCF12 IGFBP4
TREM1 STIM1 NRP1 ITGA11 AKAP13 SECTM1 EGLN2 SBNO1 CD40 MDK GNRH1 RELA LRP6
GSK3B TLR3 LTB4R NR2F6 DLL4 PGF CCL21 IGFBP3 POFUT1 TNFRSF14 NR2C2 GPC4 DEAF1
RORA MGP IL2RG SEMA4A CD8A NR4A2 LY6E CSF1 IFI30 DLL1 SLIT3 NGFR NR2F1 HLA-DRB1
FAS PCAF SFRP4 NR4A1 ATRN MED12 ITGB5 CD14 BST1 CNTN1 TNFRSF1B CREBBP GRN
GPX4 SERPINE2 TLR4 KPNA1 LAT NPC2 PLP2 ANPEP NCK2 ARNTL DTX1 CD164 NR3C1 RARG
FRAT2 STAT6 RP13-297E16.1 SMO NOTCH2 NOTCH1
NOTCH3 NOTCH4 LILRB4 LRP5 56 12 CCL24 CCR4
CCL27 SIPA1 CCL16 CCR5 CCL26 IFNG CCR2 AFP CCL11 CCL19 CCL28 CCL18 TNF CXCL12
SRM TXK CCL5 TNFAIP6 CCL23 CCL4 GNA14 LOC146909 ATP1A3 CCL13 IGFBP1 CCL7
ZNF32 CCL1 IL16 CCR8 CCR6 CCL21 CD97 IL10 SAA2 CD52 CSRP3 CCL8 CXCR4 RPS4Y1
CCL2 ARRB1 GRIN1 CXCR6 KCNH3 CCL15 CCL17 CCL22 CCL3 GZMK CCL25 CCR1 NAALADL2
CCL3L3 CCR2 CCBP2 CCR4
FY CXCR3 CCR10 CCR5 CCR6 PRLR CCR8 CCR1 CCR3 60 11 DAPK1 EMP2 DKK1
EMP1 RYR2 LEPR FZD7 ERBB4 NEO1 MARK4 SERPINF1 THBS4 NOTCH3 TNFRSF21 EDNRB
BMP7 SPG7 PLXNB1 KITLG ECM1 CHRNA5 PRKAA1 SLIT2 EMD NRCAM PPAP2A EFNB1 TGFBR3
NOTCH2 LAMA4 ROR1 NTN1 HMGCR LRP6 FZD1 AGRN PPAP2B DEDD2 EDNRA FST SPOCK2
SEMA4A APP NLGN2 FAS RTN4 STK17A ROR2 ITGA2 UNC5B TAZ FRZB GJA1 SERPINE2 CTGF
IGF1R ELN ANPEP DCBLD2 SMO NOTCH2 UNC5B
NRXN3 LRP6 NOTCH4 CELSR2 DCC UNC5C HTR3A NEO1 LRP5 95 6 LGMN ABCA1
SCARB1 SNTB1 COX8A TNFRSF1A SELT PVRL1 HDDC2 VLDLR SPPL2B PLOD3 CLCN6 APOL1
MMP9 SLCO3A1 LTF MMP13 LYPLA3 ARSD F8 PLTP CALR PAPPA CTSH SEMA6A DDOST PIGK
GFRA1 CALU DHCR24 ITGB1BP1 RELN MMP19 TBXAS1 ICAM1 CTSB SGSH CYP2J2 FBN2
APBB1 LMAN1 PPAP2A SDC2 CHKA PMPCB FURIN GULP1 MMP17 LRPAP1 MMP15 PLCB4 DAB1
TIMP2 SBNO1 BACE1 SERPINE1 CD82 LRP6 SULF1 ARTS-1 CYP7B1 DMPK MFHAS1 PDGFB
GALC CYP3A5 APP SPPL2A LPL MMP16 TXNDC4 C4BPA APOB MANBA THY1 GSN PSMB6
RNF130 GCA APOE IGF2R STARD3 MMP14 NOMO1 CANX FDXR LDLR CPD TAP2 APOD SNX17
ADAM19 HLA-DMB RP13-297E16.1 LDLR LRP1 LRP2
LRP8 VLDLR SCARF1 130 4 HSPA5 FAT2
SPTLC1 PTGDS EIF2C3 ABCA1 EFNB2 RPN1 SCARB1 SNTB1 BACE2 FBN1 SNN SELT POMT1
VLDLR SRPX2 APOL1 NRP2 PTPRN2 SLCO3A1 BGN TGFBI MAN1A1 MRPL27 ARSD ACACA
MRPS12 PLTP AGPAT3 LARS2 B3GNT3 C1S ACACB MRPS22 ATP6V0A1 EIF2B4 PTGS1 PIGK
TRIP11 NT5E MRPL21 DHCR24 UGCGL2 ZNF198 PTPN9 ACP2 RQCD1 ABCD4 TBXAS1 OSMR
ICAM1 SGSH LRRC17 MRPS18A PIGO NPR1 FBN2 LMAN1 MRPS5 CHKA SOS1 FURIN PMM2
LRPAP1 POLR3D PPGB PLCB4 THBS2 GLT25D2 PVRL2 KIAA0090 SERPINE1 FDX1 SULF1
C20orf155 TLR3 AGR2 NDST1 CYP51A1 HSD17B2 CYP7B1 APOC1 DMPK EIF2AK3 MMP2 LCAT
MGP ECHS1 LRP8 GALC LY6E CYP3A5 MGAT2 GGTLA1 SSR4 CLU MARS ANGPTL2 TXNDC4
APOB SGNE1 ARHGAP11A MED12 KDELR2 HBXAP ALDH6A1 APOE C1R BCAP31 DGKE STARD3
AGPAT1 AP1M2 MMP14 POLG2 MRPL47 FDXR HARSL BF RPLP2 FKBP9 MAST2 APOD SNX17
LARGE CDC91L1 B4GALT1 OXCT1 RP13-297E16.1 LDLR LRP1 LRP2
LRP8 85 5 SOCS3 MYLK LIFR
SMARCA2 NRG1 BRD4 ADAMTS2 CNTNAP1 ITGB3 MCAM SHB THBS4 F2R CEACAM1 SOCS2 JUP
BRD3 PML CTNNB1 MLLT4 MAP2K3 CD81 BRAF CRK FRS2 ITGA8 GNA11 GRB10 WNK1 NEDD9
NPR2 EFS RIN2 ABI1 TRIM23 STAT5A COL4A5 MAP3K7 ITPR2 CAV1 PIK3R4 FGFR2 PAK4
MAP2K5 PINK1 MAP2K4 IRS1 MAP4K4 LU ERBB2IP MINK1 CASK MAPKAPK5 ID3 STAT5B
HRMT1L1 USP6NL PCAF HIPK2 BIRC2 TRIM38 COL4A1 EPHB6 CNTN1 MAP3K10 PKN2 RET
CSNK1E MFAP4 PALLD STK3 EPHA7 MID1 RHOB ITPR3 MAP4K5 DST ARNT DOCK1 MAPK6
PPFIA1 WEE1 SMARCA4 TSC1 STAT6 PAQR3 PVRL2
GFRA1 PTPRF EDG1 59 7 CP DKK1 SCARB1
LEPR CDH13 VLDLR SERPINF1 LRP5 NOTCH3 SEMA3C CELSR2 BCHE KIAA0152 PLXNB1
KITLG ECM1 TRPC4AP F25965 TMEM59 RELN CYP2J2 AXIN1 CHKA SERHL TGFBR3 PSAP
NOTCH2 RAMP3 ITGA6 GNRH1 FDX1 LAMC1 FZD3 SULF1 LRP2 EGF ATAD2 DKK2 LRP8 CSF1
ZNRF4 DCX APP CELSR1 SFRP4 SGNE1 ROR2 LAMB2 ITGB5 MFAP5 IGF2R DGKE CTSD IL6R
GRN LDLR LRP1 APOD FRAT2 LRP6 PLXNA1
LRP8 LRP5 GNRHR VLDLR TLR10 23 17 OPRD1 NPY GNAL
GNAT2 GNAT1 GNA15 GNA11 SAC GNA13 GNAI3 TAC3 GNAZ ARR3 GNAS GNAI2 GRK1 FGF10
P2RY1 KRTAP4-5 GRM1 DRD1 SAG FSHB EDNRA PTGIR
NPY1R LHCGR 75 5 ABCA1 SCARB1
SNTB1 PCDHGC3 COX8A TNFRSF1A SELT PVRL1 HDDC2 VLDLR PLOD3 APOL1 SLCO3A1 LTF
MMP13 ARSD F8 PLTP CALR SEMA6A DDOST GFRA1 CALU DHCR24 ITGB1BP1 TBXAS1 ICAM1
SGSH CYP2J2 FBN2 APBB1 PPAP2A SDC2 CHKA MAP3K4 FURIN GULP1 MMP17 LRPAP1 MMP15
PLCB4 TIMP2 SBNO1 MDK SERPINE1 CD82 SULF1 TRA1 CYP7B1 DMPK MFHAS1 PDGFB
CYP3A5 APP LPL MMP16 C4BPA APOB LTBP1 MANBA THY1 GSN SPP1 GCA APOE MMP14
NOMO1 CANX PLAUR FDXR LDLR APOD SNX17 HLA-DMB RP13-297E16.1 LDLR LRP1 LRP8
SCARF1 CD44 62 6 SFRP1 DSC2 TPT1
HDDC2 CSPG2 M6PR NRP2 SERPINF1 COL14A1 TGFBI NEU1 H3F3B EIF4A1 VIL2 CALR SRPX
EIF4A2 HSPCA HLA-A CALU PKD1 ZNF198 ADM RQCD1 ICAM1 ACTB SELE LMAN1 ITGB4
PTPRB SOS1 FURIN ALCAM COL1A1 EDIL3 THBS2 HYOU1 DMP1 TIMP2 SULF1 TRA1 DMPK
GRSF1 MMP2 MFHAS1 RNASE4 PKD2 IL6ST CD74 TEGT SFRP4 ARHGAP11A MANBA SPP1 DGKE
GNB2L1 COL5A1 IFNAR1 APOD DCBLD2 OXCT1 CD68 EMR3 LDLR LRP1
DGCR2 TFG CD44 74 5 ABCA1 SCARB1
SNTB1 PCDHGC3 COX8A TNFRSF1A SELT PVRL1 HDDC2 VLDLR PLOD3 APOL1 SLCO3A1 LTF
MMP13 ARSD F8 PLTP CALR SEMA6A DDOST GFRA1 CALU DHCR24 ITGB1BP1 TBXAS1 ICAM1
SGSH CYP2J2 FBN2 APBB1 PPAP2A SDC2 CHKA MAP3K4 FURIN GULP1 MMP17 LRPAP1 MMP15
PLCB4 TIMP2 SBNO1 MDK SERPINE1 CD82 SULF1 TRA1 CYP7B1 DMPK MFHAS1 PDGFB
CYP3A5 APP LPL MMP16 C4BPA APOB LTBP1 MANBA THY1 GSN SPP1 GCA APOE MMP14
NOMO1 CANX FDXR LDLR APOD SNX17 HLA-DMB RP13-297E16.1 LDLR LRP1 LRP8
SCARF1 CD44 22 16 GNA12 INHA GNAL
GNAT2 GNAT1 GNA15 GNA11 GNA13 GNAI3 TAC3 GRK6 GNAZ ARR3 GNAS GNAI2 GRK1
GABRG2 TSHB KRTAP4-5 KIAA1912 SAG FSHB NPY1R LHCGR F2R
TSHR 23 15 OPRD1 NPY GNAL
GNAT2 GNAT1 GNA15 GNA11 SAC GNA13 GNAI3 TAC3 GNAZ ARR3 GNAS GNAI2 GRK1 FGF10
P2RY1 KRTAP4-5 GRM1 DRD1 SAG FSHB EDNRA PTGIR
NPY1R LHCGR 56 6 DAPK1 EMP2 EMP1
RYR2 LEPR FZD7 NEO1 MARK4 THBS4 TNFRSF21 EDNRB BMP7 ALS2CR3 SPG7 KITLG BRSK1
GCG HAND2 GIPR CHRNA5 PRKAA1 EMD NRCAM PPAP2A TGFBR3 NOTCH2 LOC115098 MYL3
LAMA4 NTN1 HMGCR KCNAB3 LRP6 FZD1 PPAP2B DEDD2 EDNRA ANGPTL3 FST SPAG11
SPOCK2 SPINT3 NLGN2 FAS RTN4 STK17A PLP1 UNC5B TAZ LOC114984 FRZB GJA1 ELN
CACNG2 DCBLD2 SMO UNC5B GLP2R
UNC5C HTR3A MLNR MTNR1B 47 6 DAPK1 EMP2 EMP1
RYR2 LEPR FZD7 ERBB4 NEO1 MARK4 THBS4 TNFRSF21 EDNRB BMP7 SPG7 KITLG CHRNA5
PRKAA1 SLIT2 EMD NRCAM PPAP2A TGFBR3 NOTCH2 LAMA4 NTN1 HMGCR LRP6 FZD1 AGRN
PPAP2B DEDD2 EDNRA FST SPOCK2 NLGN2 FAS RTN4 STK17A ITGA2 UNC5B TAZ FRZB GJA1
ROCK2 ELN DCBLD2 SMO UNC5B NRXN3
CELSR2 DCC UNC5C HTR3A 25 11 HIVEP3 CD83
TRAF3 TTRAP CD40LG EXOC8 TRAF5 TNF TRAF2 TNFSF9 IL7 CD79B MS4A1 DIABLO TRAF6
TNFSF14 CD79A ZNF597 LTA TNFSF13B NRIP1 TRAF1 TRIP TNFSF8 ANKIB1 CD40 TNFRSF8
TNFRSF11A TNFRSF1B TNFRSF4 TNFRSF9 LTBR TNFRSF13B TNFRSF19 TNFRSF14 TNFRSF17 21 12 CCR7 LGALS4
ADORA1 ITGAX GAB3 TAS1R2 CD48 GUCA1B CR2 FABP5 MOV10L1 HOMER1 USP26 EXOSC9
CASR ECEL1 KLRD1 DENND1C QSCN6L1 GPR18 SIAE GPR18 KLRK1
GUCY2F FCER2 KLRC3 DRD1 OR6A2 TAS1R3 GRM1 CCR7 GUCY2D P2RY1 109 2 ITGB1BP2 PLAU
PREX1 ELF1 CLSTN1 GPR56 PROCR ITGA10 AP2M1 F3 SPINK5 NR1H2 CNTNAP1 PVRL1
PDLIM1 BAT1 CSPG2 LILRB2 STC1 MAPRE2 SF1 SLCO3A1 TGFBI ICOSLG TRIM28 STC2
ACTG1 C1QG ZYX MLLT4 KITLG CD81 TUBB CCT3 CDH3 COL11A1 ITGA8 TRAP1 ITGB1BP1
DEK CSTB DNAJB6 CXCL12 DSTN TJP1 CXCL6 PRKDC YWHAH LTBR CD151 ADAM15 CD9 VIM
ITGAE FGF7 ITGA11 ITGA1 YWHAB ARHGAP5 C1QB CDH23 FSCN1 MFGE8 RAD21 ACHE YWHAZ
RFXANK C1QR1 C3AR1 CD24 LGALS3BP ACTN1 MAP4K4 TNFRSF14 HMGN2 KNS2 HLA-DMA
ITGA4 C1QA NME1 CD74 DSG2 FLNA EPAS1 CD58 COL4A1 F2RL2 MST1 MMRN1 F11R MFAP5
C1R DIAPH1 CCT8 VCAM1 GPX4 CANX SMAD4 LGALS8 FLNB CD36 DST MAST2 TLN1 ITGA9
MCP DOCK9 CRIM1 RP13-297E16.1 ITGB7 ITGB1 19 11 NPHS1 OR1E1
GNAT2 GNAT1 GNA11 OR7C1 GNAI3 TAC3 OR1N1 GNAZ ARR3 GNAI2 GRK1 OR1F1 IGKV1-13
OR1G1 OR1D2 SAG OR1E2 NPY1R OR1D4 23 9 CPNE4 ATG4C
ZNF566 DMRTC1 LSP1 HTR1E HTR1F CCKBR ITGAL GUCY2C CCL20 XCL1 CXCR3 HTR1D SAA2
PKN1 FLJ31222 HTR1B KIAA1443 DEFB4 F11 TBX21 CXCL10 OPN4 HTR1B
HTR1F OR2C1 CCKAR FPRL1 HTR1E HTR1A CCR6 53 3 ATF4 RTN3 TPT1
AP2M1 PBP CALM1 TMEM66 NOL5A PSME3 FXYD5 H3F3B EIF4A1 HSPCA PPP2R1A CCT3
SLC3A2 HDLBP LDHA GPI KIAA0174 K-ALPHA-1 CTNNA1 ACTB ATP5A1 DDX5 PKM2 2-Sep
HADHB FLJ22555 NONO UBC ARPC5 SPOP EIF3S6IP STX12 VCP CIRBP YWHAE WBP2 DCTN2
CD74 RPL4 TEGT ENO1 HSPCB WARS FUS GNB2L1 TXNIP ALDOA SNX17 RAB7 SFRS2 TNFRSF1A DGCR2
TFG 67 2 TRAM1 PLAU LGMN
PROCR FBN1 F3 FOXK2 RCN2 ABCD3 IF SEMA3C 76P CALR CD59 C2 ACSL4 ATP6V0A1 GPX3
VGLL4 TMEM59 ANXA5 ACP2 FGG TFPI2 IDH3B LMAN1 EXT1 ALCAM TCF12 RNASE1 EI24
IL20RA CX3CL1 IFNGR1 SERPINE1 LAMC1 TYROBP MSRA SERPIND1 CD24 CYP51A1
SERPINH1 TRA1 GRSF1 CLU IFNGR2 PON2 LPL GSTT1 LAMP2 SPP1 CD14 C4A CD58 F2RL2
BCAP31 NCSTN HSPA4 SDC4 KATNB1 BF PTX3 SRD5A1 ASAH1 ITGA3 GPX7 APOD ATRN GPR128 20 6 PRKCSH HLA-B
CSPG2 PPY2 HLA-G HLA-E KLRC2 SYAP1 FVT1 KLRC1 AKAP13 KRTAP9-8 TIMP2 KLRC3
C1QTNF5 CD226 SLC4A10 IL10RB KLRD1 ZC3HAV1 UPK1B EMR3
KLRD1 KLRC2 KLRC1 MAS1 21 4 ABCA1 DAB2 LRP5
DLG4 ACACA PIGK CUBN PSAP LPA DAB1 SERPINE1 GPRASP1 POFUT1 LRP2BP TUFM APOB
ANKRA2 STARD3 AGPAT1 EB-1 SORL1 LRP2 HTR2C IL13RA1 BAI2 14 6 IL17F IL12B NSUN3 TLR2 IL21 IL12RB2 FANCL MYH11 SON C14orf118 TLR4
MGC13017 IFNB1 NALP12 TLR1 TLR3 IL21R ADORA2A TLR6 IL12RB1 20 4 AVPR1B OR2B2 HAND2 EPB41 RP13-383K5.1 CLEC11A C14orf80 OR10C1 HB-1 OR2K2
OR2B6 PHF2 PNPLA5 PLA2G7 PAX2 POU3F1 KIAA0523 MMP27 PKLR DEFB103A MAS1L OR2F1
OR5V1 P2RY8 13 6 NPHS1 OR1E1
TRPC4AP F25965 SERHL OR7C1 OR1N1 ATAD2 ZNRF4 DCX IGKV1-13 OR1G1 OR1E2 OR1D4 OR1A1
OR7A17 TLR10 OR1A2 OR1D2 11 7 NPHS1 OR1E1
OR2B2 OR7C1 OR1N1 OR2B6 OR1F1 IGKV1-13 OR1G1 OR1D2 OR1E2 OR1D4 OR1A1
OR5V1 OR7C2 OR7A17 OR1A2 OR1D2 9 6 NPHS1 OR1E1
OR7C1 OR1N1 OR1F1 IGKV1-13 OR1G1 OR1D2 OR1E2 OR1D4 OR1A1
OR7C2 OR7A17 OR1A2 OR1D2 9 5 C16orf50 KNDC1
SLMAP ZFY OR1F1 OR7C2 SYT7 OR7A17 OR1D2 OR1E1 OR1G1
OR7C1 OR7C2 OR1F1 15 3 ALS2CR3
MGC15631 PABPC4 BRSK1 GCG GIPR TRPS1 KCNAB3 ANGPTL3 PCGF1 KIF1A PLP1 LOC284912
LOC114984 CACNG2 GLP2R GPR20
MTNR1B 10 4 OR1N1 C16orf50
KNDC1 SLMAP ZFY OR1F1 OR7C2 SYT7 OR7A17 OR1D2 OR1E1 OR7C1
OR7C2 OR1F1 5 3 OR2B2 C14orf80
OR2K2 OR2B6 OR1F1 OR2F1 OR5V1
OR7C2 |
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