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Hydrophobicity (reference Chapter 5, Ref_Lesk)

The hydrophobic nature of some amino acid side chains is important for the stability of the native state (see "ab initio protein structure prediction") and consequently for the protein folding process. Here are some studies regarding the distribution of hydrophobic amino acids along protein sequences, and their applications in structure predictions:

1. Prediction of turns between secondary structure elements using hydrophobicity

2. Distinguish exposed and buried sites using hydrophobicity

3. Prediction of transmembrane regions using hydrophobicity

4. Prediction of antigenic sites using hydrophobicity

5. Statistical distribution of hydrophobic residues along protein sequences (ref. Schwartz/King)