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Measures of functional similarity

there is no quantitative measure of functional relatedness as in structural relatedness

attempts:

ENZYME based on EC codes

GenProtEC/EcoCyc for E. coli

MIPS for yeast

Ashburners' functional classification for Drosophila

EGAD for human ESTs

synthesis of these attempts into global databases:

KEGG

WIT

GO

Other approaches in Wilson et al 2000